Ali Davoodi
Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Medicinal Plants Research Center, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
[ 1 ] - Materia Medica Used in Jaundice Based on Persian Medicine
Jaundice is recognized by increased bilirubin level of blood and yellow appearance in skin, sclera and mucous membrane. Natural products have been used for treatment of jaundice for a long time and Persian Medicine can be a good source of natural drugs for this purpose. This study was done to find the materia medica used for jaundice based on Persian medicine (PM) texts including The Canon of M...
[ 2 ] - Starting Dose Calculation for Medicinal Plants in Animal Studies; Recommendation of a Simple and Reliable Method
Background and purpose: Research studies indicate that almost 80% of the present day drugs are derived directly or indirectly from medicinal plants. The estimation of a safe starting dose is a concern when a new substance is to be investigated including medicinal plants, in clinical and laboratory studies. This study was intended to explore a simple and reliable method of calcu...
[ 3 ] - بررسی اثرات ضد سرطانی سنه سیونین و پیرگیاه در رده های سلولی سرطانی پروستات
Background and purpose: This research aimed at evaluating the effects of senecionine and Senecio vulgaris extract on apoptosis and cell cycle inhibition. Also, their cytotoxicity on prostate cancer cell lines (PC3, DU145 and HGFs), antioxidant effects, and influences on AR and CLU gene expression were investigated. Materials and methods: In this experimental study, senecionine and S. vulgaris ...
[ 4 ] - Plant cells technology as an effective biotechnological approach for high scale production of pharmaceutical natural compounds; A meta-analysis study
Natural-based drugs are the important bioactive substances that have been used for prevention and treatment of diseases. Natural products should be prepared in commercial scale from relevant medicinal plants. Hence, large amounts of the plants have been needed for extraction and isolation of compounds of natural origin. Plant cells technology is the best strategy for the production of the plant...
[ 5 ] - Ethnobotanical Study of Medicinal Plants used in Skin Diseases in the Area Alamut-Qazvin, Iran
Background: Medicinal plants have been used for treatment of diseases and finding of new drugs. Botanical valuable traditional methods, offer finding new medicinal plants and herbal medicines. Objective: The aim of this study was the identification of important medicinal plants that widely were used by local inhabitants, in the treatment of skin diseases in the area of Alamut-Qazvin, Iran. M...
[ 6 ] - Effect of Prunus Mahaleb L. Seed Extract on Ethylene glycol- and Ammonium Chloride-Induced Urolithiasis in BALB/c Mice
Background: Kidney stone disease can be quite painful, recurrent, and affects many people. Despite advances in drug therapy, there is still a need to find effective drugs with fewer complications for long-term treatment of kidney stones and to prevent its recurrence. The present study aimed to evaluate the effect of Prunus mahaleb L. seed extract on ethylene glycol- and ammonium chloride-induce...
[ 7 ] - Optimization of Ultrasound-assisted Acidic-solvent Extraction of Colchicine from Colchicum kurdicum (Bornm.) Stef. Using Response Surface Methodology
Background and objectives: Colchicum kurdicum (Bornm.) Stef. is a flowering perennial monocotyledon plant that has many important bioactive compounds especially colchicine and colchicine derivatives. In this study, the ultrasound-assisted acidic-solvent extraction method coupled with response-surface method was presented as the successful method for large scale extract...
[ 8 ] - Evaluation of therapeutic strategies of neonatal jaundice by medicinal herbalists of Mazandaran province: a descriptive cross sectional study
Background: Neonatal jaundice is as a disease caused by the abnormality of bilirubin metabolism that tendency of people to traditional medicine is very high for the treatment. Objective: The aim of this study was to determine the therapeutic strategies, especially herbal treatments, in the neonatal jaundice, for mother and infant, based on verbally traditional medicine recommended by medicinal ...
[ 9 ] - A Mini-Review on Iron Chelating Agents as a Promising Therapeutic Target in Treatment of Leishmaniasis
There is a high prevalence of infections caused by Leishmania parasites and increasing rate of drug resistance. Lack of successful treatment with existing drugs calls for new therapeutic approaches. The main strategy in treatment of leishmaniasis is creating apoptosis and eliminating different forms of the parasite. So far, numerous drugs with specific mechanisms including 14-α-demethylase enzy...
[ 10 ] - Optimization of Colchicine Extraction from Colchicum Kurdicum (Bornm.) Stef. Corm and Evaluating Anti-Inflammatory and Anti-Oxidant Activities of the Plant Extract
Background and purpose: Colchicum kurdicum (Bornm.) Stef. is a monocotyledon plant which is endemic to Iran. The corm and seeds of this plant have some bioactive compounds, especially tropolone alkaloids that are used in treatment of inflammations, rheumatoid arthritis, gout, joint pains, and cancers. This study aimed at optimization of colchicine extraction from the corms of C. kurdicum and ev...
[ 11 ] - Protective Effect of Sankol Herbal Product on Kidney Stone in Balb/C Mice
Background and purpose: Kidney stone is a common form of kidney disease and many efforts have been made to find medications for its prevention and treatment. Current study evaluated the protective effects of Sankol herbal product in the formation of renal stone in male Balb/c mice. Materials and methods: Nephrolithiasis was induced in male Balb/C mice within 21 days by adding 75% ethylene glyc...
[ 12 ] - Antibacterial Activities of Gel Containing 5% Hydroalcoholic Extract of Rhamnus cathartica L. bark
Background and purpose: Acne is a chronic inflammatory disease of the pilosebaceous glands caused by opportunistic microorganisms. The Rhamnus cathartica is known to have biological and antioxidant properties. This research aimed at investigating the in vitro effect of gel containing 5% R. cathartica extract on acne vulgaris. Materials and methods: The gel formulation contained 25g of dried R...
[ 13 ] - Response surface methodology for optimization of supercritical fluid extraction of orange peel essential oil
Background: Orange peel essential oils were obtained using supercritical fluid extraction. This method is an important high scaling extraction methods that used for extraction of plant and animal extracts. Methodology: The experimental parameters of SFE such as temperature, pressure, and extraction time and modifier volume were optimized using a central composite design after a 24-1fractional ...
[ 14 ] - Formulation, Preparation and Evaluation of Antiperspirant Effects of Hydrogel of Salvia virgata Jacq Aerial Part: A Randomized, Double Blind and Placebo-Controlled Clinical Trial
Background and purpose: Salvia virgata Jacq has antioxidant, antibacterial, anti-inflammatory, antinociceptive, antispasmodic, and healing effects. The aim of this study was to prepare and antiperspirant clinical evaluation of aerial gel formulation of this plant. Materials and methods: The aerial parts of the plant were collected from Hezarjarib forest in Mazandaran, spring 2017. The samples ...
[ 15 ] - Effect of Lipogel Containing Extracts of Eryngium campestre L. and Satureja hortensis L. on Wound Healing in Male Wistar Rats
Background and purpose: Wound is a type of injury with high prevalence in the society. The main requirement for wound management is rapid and complete wound healing without the spread of infection. Medicinal plants are affordable and accessible and suggested as one of the key treatment options. The aim of this study was to investigate the effect of lipogel formulations containing the extract...
[ 16 ] - Antimicrobial and Synergistic Effects of Garlic and Cinnamon Extract Compared with Fluoride Varnish on Oral Lactobacillus acidophilus and Streptococcus mutans in Laboratory Conditions
Background and purpose: Garlic and cinnamon extracts, like fluoride varnish, play a role in caries control due to their antimicrobial effect and controlling demineralization. This analytical laboratory study was conducted in 2021 to investigate the antimicrobial effect of garlic and cinnamon extracts compared with fluoride varnish in controlling the infection of oral Lactobacillus acidophilus a...
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