Nejat Kheiripour
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical ciences, Kashan, Iran
[ 1 ] - Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver
Objective (s): Cerium oxide nanoparticles nanoceria (CeNPs) is a novel nanoparticle that has great potential for the treatment of various diseases. This study aimed to investigate the effects of CeNPs on oxidative stress biomarkers in the liver of male rats. Materials and Methods: Twenty-four male Wistar rats were equally distributed into 4 groups (n=6/each). The first group was controlled and ...
[ 2 ] - بررسی اثر سیلی مارین بر بیان ژن های اوروتنسین 2 و گیرنده آن در بافت کبد رتهای دیابتی تیپ 2
سابقه و هدف: مطالعات نشان میدهند که افزایش U-IIبا اختلالات دیابت مرتبط میباشد. با توجه به اینکه داروهای گیاهی برای درمان بیماری نسبت به بسیاری از داروهای شیمیایی عوارض کمتری دارند، در این مطالعه اثر سیلیمارین بر سطوح گلوکز، انسولین و بیان ژنهایU-II و گیرنده اوروتنسین2 (U-II R) در رتهای نر دیابتی تیپ2 مورد بررسی قرار گرفت. مواد و روش ها: در این مطالعه تجربی 36رت نر ویستار آلبینو به‌صورت ت...
[ 3 ] - Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes
Objective(s): One of the serious complications of Type1 diabetes (T1D) is diabetic nephropathy, which is accompanied with overexpression of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) and enhanced oxidative stress. The present study was conducted to examine the protective effect of curcumin on the expression of KIM-1, NGAL genes and oxidative damage in...
[ 4 ] - Hepatoprotective Effects of Silymarin on Liver Injury via Irisin Upregulation and Oxidative Stress Reduction in Rats with Type 2 Diabetes
Background: Diabetes is one of the most prevalent metabolic diseases. Irisin (FNDC5 protein) is involved in the new strategy of combating type 2 diabetes. In the liver, the antidiabetic mechanism of silymarin at the molecular level is unknown. This study investigated the effects of silymarin on irisin and the related gene expression and oxidative stress status in the liver of type 2 diabetic ra...
[ 5 ] - EEffects of nano-curcumin and curcumin on the oxidant and antioxidant system of the liver mitochondria in aluminum phosphide-induced experimental toxicity
Objective(s): Aluminum phosphide (AlP) is commonly used pesticide which could cause poisoning mainly through the induction of oxidative stress. The present study aimed to evaluate the effects of nano-curcumin and curcumin on the oxidant and antioxidant system in the liver mitochondria using AIP-induced toxicity model.Materials and Methods: In this study, 36 male albino Wistar rats were ra...
[ 6 ] - Evaluation of the Protective Effects of Hydroalcoholic Extract of Satureja avromanica Against Malathion-induced Oxidative Stress in the Liver: An Experimental Study
Background: Studies have shown that organophosphorus pesticides such as malathion induces oxidative stress injury and tissue damage. Objectives: This research aimed to determine the effects of the hydroalcoholic extracts of Satureja avromanica (SA) on the liver function of malathion-poisoned animals. Methods: Twenty-eight rats were divided into four groups of the control, SA (20 mg/kg), mala...
[ 7 ] - Antioxidative Effects of Nano-curcumin on Liver Mitochondria Function in Paraquat-induced Oxidative Stress
Background: Paraquat (PQ), as the most widely used herbicide in agriculture, induces poisoning in humans and animals mainly through oxidative stress. This study aimed to investigate the protective effects of nano-curcumin compared with curcumin against PQ-induced mitochondrial dysfunction. Materials and Methods: Thirty-six Wistar rats were used in this study. They were separated into 6 groups...
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