Azeez Olakunle Ishola
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Nigeria.
[ 1 ] - Spatial Memory, Motor Coordination, Cerebellar and Hippocampal Histoarchitectural Changes following Atropine Administration to Adult Mice
Atropine is a non-selective muscarinic receptor antagonist. In overdoses, atropine is poisonous. It is sometimes added to potentially addictive drugs, particularly anti-diarrhoea opioid drugs such as diphenoxylate or difenoxin. The aim of this study was to investigate spatial memory and motor changes associated with varying doses (5 and 10 mg/kg body weight) ingestion of atropine, as well as it...
[ 2 ] - Datumetine Preferentially Upregulates NMDAR Signalling Pathways in Different Brain Regions of Mice
Background: We earlier reported that datumetine possesses binding affinity with NMDAR and that 14-day exposure to datumetine altered NMDAR signalling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice. Results: Relative to Veh, datumetine downregulate the expression of CamKIIα i...
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