Shima Zare-shahamati

[ 1 ] - A comprehensive approach to investigate the contradictory effects of metformin therapy in cerebral ischemic injury

Ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. Metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. Metformin can either protect or damage cells by activating AMP-activated protein kinase (AMPK) and its downstream factors so, it has a dual role in the cerebral ischemia context, bu...