Leila Khalaj

Medical School, Alborz University of Medical Sciences, Alborz, Iran

[ 1 ] - Gemfibrozil protect PC12 cells through modulation of Estradiol receptors against oxidative stress

Introduction: Neurodegenerative diseases are progressive disorders that could impair neuronal functions and structures. Oxidative stress and mitochondrial dysfunction are involved in the etiology of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and etc. Gemfibrozil is used as a therapeutic drug for hyperlipidemia. It has been shown that gemfibrozil is n...

[ 2 ] - A comprehensive approach to investigate the contradictory effects of metformin therapy in cerebral ischemic injury

Ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. Metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. Metformin can either protect or damage cells by activating AMP-activated protein kinase (AMPK) and its downstream factors so, it has a dual role in the cerebral ischemia context, bu...