Abolghasem Danesh
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
[ 1 ] - Marine Actinomycetes with Probiotic Potential and Bioactivity Against Multidrug-resistant Bacteria
Considering antimicrobial resistance problem, marine microorganisms with the bioactivity against multi-drug resistant (MDR) pathogens have attracted many scientific interests. To address this issue, a total of 21 marine actinomycetes isolated from the Caspian Sea have been screened out. Primary screening via cross-streak method revealed that 3 strains: MN2, MN39, and MN40 produce antimicrobial ...
[ 2 ] - Isolation and Identification of a Rare Actinomycete with Antibacterial Activity from Saline Region of Iran
Background: The appearance of multi-drug resistant microorganisms is becoming a global problem. Already several strategies have been employed to overcome antibiotic resistance issue. Developing new antimicrobial compounds from microbial sources could be a beneficial solution. Hence screening programs in order to discover new antibiotics from microbial entities are interesting. Because of high c...
[ 3 ] - Development of a Plaque Reduction Assay as an Antiphage Activity Evaluation Method
Background: Antiviral screening of newly isolated or synthesized compounds is an important matter which requires a reliable antiviral test. In order to address this issue, the development of a rapid antiphage test has been conducted. To achieve this goal, the antiphage activity of three antiviral drugs (Acyclovir, Lamivudine and Trifluridin) against phage CP51 which infects Bacillus cereus (ATC...
[ 4 ] - Anti-MRSA activity of a bioactive compound produced by a marine Streptomyces and its optimization using statistical experimental design
Objective(s): To address the alarming problem of methicillin-resistant Staphylococcus aureus (MRSA), herein, a marine Streptomyces capable of producing an anti-MRSA compound has been studied.Materials and Methods: Strain MN41 was morphologically and physiologically characterized and then, molecularly identified using 16SrRNA analysis. To...
[ 5 ] - An Increase in Antimicrobial Effects of Standard Antibiotics in Combination with the Active Metabolites Isolated from Marine Streptomyces: A Laboratory Study
Background and Objectives: Combination therapy has been considered as a potential approach to overcome antimicrobial resistance. In this study the antimicrobial effects of active compounds produced by some marine Streptomyces spp. in combination with some standard antibiotics against multidrug-resistant pathogens was investigated. Materials and Methods: In this laboratory study, the bacteria i...
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