محمد مهدی یعقوبی
عضو هیات علمی پژوهشگاه علوم و تکنولوژی پیشرفته و علوم محیطی کرمان
[ 1 ] - اثرات عصاره آبی و اتانولی گل محمدی (Rosa damascena mill L.) بر علیه سلولهای سرطانی معده انسان
مقدمه: سرطان معده یکی از عوامل مهم بیماری و مرگ و میر در جهان است. گونه‌های گیاهی منحصر به فرد زیادی وجود دارد که برای یافتن ترکیبات ضد سرطانی باید مطالعه شوند. هدف: در این تحقیق، خاصیت ضد سرطانی عصاره اتانولی و آبی گل محمدی بر رده سلولهای سرطانی معده انسان (AGS) بررسی شد. روش بررسی: هشت غلظت متفاوت از عصاره‌ها به همراه داروی 5- فلورواوراسیل بر روی رده سلولی سرطان معده اعمال شد. سمّیت عصاره‌ها ...
[ 2 ] - Cytotoxic and anti-proliferative effects of Rosa beggeriana Schrenk extracts on human liver and breast cancer cells
Objective: Rosa beggeriana Schrenk has been consumed in Iranian traditional medicine. In contrary to its close species (e.g. R. canina), there is no data on its medicinal properties. Therefore, we explored possible cytotoxic effects of R. beggeriana against two cancer cell lines. Materials and Methods: The cytotoxic and anti-pro...
[ 3 ] - The effect of aqueous and ethanolic extracts of Sedum album L. on human stomach and breast carcinoma cell lines in vitro
In this study, the cytotoxic effects of aqueous and ethanolic extracts of Sedum album L. on human stomach cancer cell line (AGS) and breast cancer cell line (MCF-7) were evaluated by MTT, BrdU and TUNEL assays. The results demonstrated that both extracts had antiproliferative and apoptotic effects in a dose-dependent manner. The MTT assay data revealed that the AGS cell underwent more cytotoxic...
[ 4 ] - Ethanolic Extract of Propolis from Kerman Area Triggers Apoptosis and Arrests Cell Cycle in Three Human Breast Cancer Cell Lines MDA-MB-231, SKBR and MCF-7
Background: Cancer is one of the major health problems worldwide and natural resources are being explored to develop anticancer drugs with fewer side effects. Iranian propolis contains components including flavonoids and polyphenols and has various medicinal properties. The aim of this study was to investigate the effect of Ethanolic Extract of Sirch Propolis (EESP) on three br...
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