Yashar Sarbaz
Department of Mechatronics, School of Engineering- Emerging Technologies, University of Tabriz, Tabriz, Iran.
[ 1 ] - Power Spectral Density Analysis of Purkinje Cell Tonic and Burst Firing Patterns From a Rat Model of Ataxia and Riluzole Treated
Introduction: Purkinje Cell (PC) output displays a complex firing pattern consisting of high frequency sodium spikes and low frequency calcium spikes, and disruption in this firing behavior may contribute to cerebellar ataxia. Riluzole, neuroprotective agent, has been demonstrated to have neuroprotective effects in cerebellar ataxia. Here, the spectral analysis of PCs firing in control, 3-acety...
[ 2 ] - Contribution of Somatic and Dendritic SK Channels in the Firing Rate of Deep Cerebellar Nuclei: Implication in Cerebellar Ataxia
Introduction: Loss of inhibitory output from Purkinje cells leads to hyperexcitability of the Deep Cerebellar Nuclei (DCN), which results in cerebellar ataxia. Also, inhibition of small-conductancecalcium-activated potassium (SK) channel increases firing rate f DCN, which could cause cerebellar ataxia. Therefore, SK channel activators can be effective in reducing the symptoms of this disease, ...
[ 3 ] - Mathematical Representation of Vasorelaxant Effect of Benzopyranes Using Box-Jenkins Model
Drug design is generally achieved through trial and error methods, which is a time and resource consuming process and novel methods are needed to improve it. Mathematical modelling is one of the possible solutions to speed up this process. In this study, we have presented Box-Jenkins model, to predict the vasorelaxant activity (pEC50) of a set of benzopyrane compounds. We used t...
[ 4 ] - The Effects of Counting the Stride Numbers on the Parkinsonian Gait: Suggesting a Possible Reason for Dual Task Interference
Introduction: Parkinson Disease (PD) is a degenerative and progressive disorder of the central nervous system. It results from degeneration of Substantia Nigra pars compacta (SNc) of the Basal Ganglia (BG). Gait disturbances in PD patients generally get worse over time. The underlying mechanism of gait disturbances in PD has not been elucidated yet. Methods: In this study, we tried to analyze ...
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