Negin Fraidouni
Student Research Committee, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
[ 1 ] - Research Paper: The Anti-Parkinsonism Effects of KATP Channel Blockade in the 6-Hydroxydopamine-Induced Animal Model: The Role of Oxidative Stress
Introduction: Studies suggest that ATP-sensitive potassium (KATP) channels are a potential pharmacotherapeutic target for neuroprotection in neurodegenerative diseases. The current study aimed at evaluating the effect of pretreatment with glibenclamide (Glib) and B vitamins supplement on the severity of behavioral symptoms in 6-hydroxydopamine (OHDA)-induced Parkinsonism. Also malondialdehyde (...
[ 2 ] - Effect of tetraethylammonium and B vitamins group on the efficacy of cell replacement therapy in the treatment of Parkinson\'s disease in the 6-hydroxydopamine animal model
Introduction: Transplantation of embryonic ventral mesencephalic (VM) dopamine neurons into the striatum is a currently explored therapeutic strategy for treatment of patients with patients with Parkinson's disease (PD). However, this strategy has been limited with poor cell survival, generally ranging from 5-20%. In this study, we investigated the effect of potassium channel blocker of tetr...
[ 3 ] - High intake of folic acid attenuates 6-hydroxydopamine-induced Parkinsonism
Introduction: High levels of homocysteine (Hcy) might accelerate dopaminergic cell death through oxidative stress and excitotoxicity. Folate plays an important role in the control of plasma levels of Hcy. In this study, effect of supplementation with folic acid on the 6-hydroxydopamine (6-OHDA)-induced Parkinsonism in rat and also serum level of Hcy was investigated. Methods: Rats were fed ...