عطایی, رامین
علوم پزشکی مازندران
[ 1 ] - بررسی ارتباط پلی مورفیسم Fok1 گیرنده ویتامین D3 با تراکم استخوان در زنان یائسه مبتلا به استئوپروز
Background and purpose: Osteoporosis is a multiple disease that is characterized by decrease in bone mass and bone strength. This decrease is more common in postmenopausal women due to decreased estrogen levels. Vitamin D3 plays a pivotal role in skeletal metabolism by binding to nuclear steroid receptors (receptors for vitamin D (VDR)). This study aimed at investigating the relationship betwee...
[ 2 ] - بررسی ارگانیسم های عامل عفونت ادراری و مقاومت آنتی بیوتیکی در نمونه کشت ادرار آزمایشگاه بیمارستان کیان شهر تهران بین سال های 91-90
Background and purpose: Urinary tract infection (UTI) is one of the most common infections and the second cause of infection in human body. In developing countries it involves at least 250 million people annually. The main cause of this infection is gram negative bacteria such as E coli. UTI is seen in all ages and both sexes but its incidences is more in female. The base of treatment for urina...
[ 3 ] - بررسی اثر مهاری ملاتونین بر رده های سلولی AGS و MKN45 آدنوکارسینوما معده
Background and purpose: Melatonin is a neurohormone with important physiologic and pharmacologic role in human body especially in circadian rhythm .In recent years, some progress has been achieved to show its role in regulating in prevention of cancer especially breast and colon cancer. According to this background and as there was not any precise cellular research about the role of melatonin i...
[ 4 ] - Homocysteine intracerebroventricular injection induces apoptosis in the Substantia Nigra cells and Parkinson like behavior in rat
Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. Homocysteine (Hcy) is a non-protein amino acid. It is a homologue of the amino acid cysteine. The elevated levels of homocysteine in p...
[ 5 ] - Interaction of Memantine with Homocysteine on the Apoptosis in the Rat Hippocampus cells
It has been hypothesized that elevated plasma Homocysteine (Hcy) plays a role in the pathogenesis of Alzheimer’s disease (AD) and age-related cognitive decline. The mechanism of Hcy neurotoxicity in the brain is controversial as well Hcy is a ligand of NMDA receptor. Memantine, an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors approved for the treatment of moderate to severe ...
[ 6 ] - Investigation of the therapeutic effect of nicotine and its metabolites on the brain
The effect of Cotinine, active metabolite of nicotine, on Aβ1-42 neurotoxicity was investigated. Cotinine possesses a longer plasma half-life, lower toxicity and it is a partial agonist of the nicotinic acetylcholine receptors (nAChR). Cotinine prolonged the survival of cortical neurons exposed to Aβ1-42. These results indicated that cotinine has a neuroprotective effect by inhibition of the fo...
[ 7 ] - Prophylactic Effect of Chloroquine and Hydroxy chloroquine in COVID-19 Treatment
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety.Hydroxychloroquine (HCQ) is an anti-malaria drug; its antiviral properties are controversial,and some in vitr...