صادق زاده, نورالله
. استاد یار، گروه داروسازی هسته ای، دانشکده داروسازی ، دانشگاه علوم پزشکی مازندران، ساری، ایران 4. مرکز تحقیقات علوم داروئی، دانشگاه علوم پزشکی مازندران، ساری، ایران
[ 1 ] - آماده سازی و ارزیابی رادیوشیمیایی HYNIC-[ Lys3,Tyr4]bombesin (3-14) نشاندار شده با تکنسیوم- m99 برای ردیابی سرطان پروستات
Background and purpose: Over-expression of GRP receptors for Bombesin has been reported to be found in malignant tissues, especially in prostate cancer. Here, we aimed at radiochemical and stability evaluation of a new bombesin derivative labeled with 99mTc via HYNIC as a chelating agent and Tricine/EDDA as coligands that might be used for diagnosis of prostate cancer. Materials and methods:...
[ 2 ] - مطالعه درون تنی و برون تنی مشتق جدیدی از بومبزین با فاصله دهنده تری گلایسین به عنوان عامل بالقوه در تصویربرداری هدفمند تومور
Background and purpose: Bombesin is a 14-amino acid peptide with high biological functions which has a high affinity to GRP )Gastrin releasing peptide( receptor. GRP receptors are overexpressed in many malignant tumors such as prostate and breast cancers. The purpose of this study was to prepare [HYNIC-(Gly)3-D-Phe13]Bombesin(7-14) to label it easily by 99mTc and to evaluate it as a potential a...
[ 3 ] - ارزیابی خلوص شیمیایی، رادیو شیمیایی و رادیو نوکلئیدی محلول به دست آمده از شویش ژنراتورتکنسیم-m99/ مولیبدن-99
Background and purpose: 99mTc is a widely used radionuclide in nuclear medicine and research nowadays. Two types of 99 Mo/99mTc generators were studied in 2013 and 2014 to test the quality of the eluates. In this study we measured the radionuclide purity for possible 99Mo breakthrough, the radiochemical purity, the pH, and the aluminum content of eluates. Materials and methods: Two type genera...
[ 4 ] - Targeted Cancer Diagnostic and Therapeutic Agents: Delivery by Carriers or Conjugation
Receptors and proteins are overexpressed in many human cancer cell membranes rather than normal tissues and are considered as the main molecular targets. Specific tumor- targeting molecules which have high affinity for these receptors can be valuable tools as carrier molecules for targeted cancer therapy and imaging. Pharmacokinetics and bioavailability of diagnostic and therapeutic agents are ...
[ 5 ] - Evaluation of a new bombesin analogue labeled with 99mTc as potential targeted tumor scintigraphic agent
Background: Bombesin shows high affinity for Gastrin-releasing peptide (GRP) receptors which over expressed on the cell surfaces of several human tumors particularly in prostate and breast cancers. The aim of this study was labeling of designed analogue with99mTc via HYNIC and Tricine /EDDA and evaluation as potential targeted tumor scintigraphic agent. Materials and Methods: HYNIC-Bombesin wa...
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