محمدی, مسلم
ساری، میدان خزر، کیلومتر 18 جاده خزر آباد، مجتمع دانشگاهی پیامبر اعظم (ص)، دانشکده پزشکی، گروه فیزیولوژی و فارماکولوژی
[ 1 ] - ترکیبات ارگانوفسفره و سیستم گابائرژیک مغز
Organophosphorus (OP) compounds are cholinesterase inhibitors widely used as pesticides in agriculture and nerve agents in battlefields. Exposure to these compounds leads to accumulation of acetylcholine at cholinergic synapses and overstimulation of muscarinic and nicotinic receptors by inhibiting the enzyme acetylcholinesterase. Seizure activity is one of the major manifestations of OP poison...
[ 2 ] - اثر ال-کارنیتین بر صلاحیت تکوینی جنین های حاصل از تخمک های موش سوری انتخاب شده با رنگ آمیزی brilliant cresyl blue بعد از پارتنوژنز
Background and purpose: Embryos produced from in vitro assisted reproductive technologies (ART) manipulations, such as parthenogenesis, are less developmentally competent than in vivo-derived embryos. This study was designed to evaluate the effect of L-carnitine treatment during IVM on maturation of immature oocytes selected by Brilliant Cresyl Blue (BCB) staining, and their subsequent developm...
[ 3 ] - تغییرات رفتاری مرتبط با اضطراب به دنبال مواجهه مکرر موش‌های صحرایی با پاراکسان
Background and purpose: Organophosphate (OP) compounds exert toxicity by inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine in cholinergic synapses and overstimulation of the cholinergic system. Hyperactivity of brain cholinergic system can contribute to the pathophysiology of anxiety. The purpose of this study was to investigate the influence of repeated ex...
[ 4 ] - Effect of paraoxon on the synaptosomal GABA uptake in rat hippocampus and cerebral cortex
Introduction: Paraoxon (the neurotoxic metabolite of organophosphorus (OP) insecticide, parathion) exerts acute toxicity by inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine in cholinergic synapses and hence overstimulation of the cholinergic system. Since, reports on changes in the level of γ- amino butyric acid (GABA) during OP-induced convulsion have bee...
[ 5 ] - Effects of Moderate Treadmill Exercise on Anxiety and Serum Corticosterone and IGF-1 Levels in A Rat Model of Post-Traumatic Stress Disorder
Background and purpose: Post-traumatic stress disorder (PTSD (is a psychotic illness caused by different types of stressors and is associated with high economic and psychological burdens on health systems. Physiological studies of the brain have shown that serum corticosterone and insulin-like growth factor 1 (IGF-1) levels have important roles during brain damage and trauma to the nervous syst...
[ 6 ] - Cognitive Function and Hippocampal Glutathione and Malondialdehyde Levels in Paraoxon-intoxicated Rats
Background and purpose: Exposure to organophosphorus (OP) compounds may contribute to an increased risk of cognitive impairments and induction of oxidative stress. The present study was designed to evaluate the effects of exposure to paraoxon (the active metabolite of insecticide parathion) on cognitive function and oxidative stress biomarkers. Materials and methods: Adult male Wistar rats (n=...
[ 7 ] - Neuroprotective Effects of Allicin on Neurological Scores, Blood Brain Barrier Permeability and Brain Edema Following Severe Traumatic Brain Injury in Male Rats: A Behavioral, Biochemical and Histological Study
Background and purpose: Allicin has a wide range of pharmacological functions, all of which can be demonstrated in anti-inflammatory, antioxidant, antifungal and anti-tumor activities. In this research, we investigated the neuroprotective role of allicin in the process of diffuse traumatic brain injury and its effect on interleukin levels and histological changes in rats. Materials and method...
[ 8 ] - Responsiveness to the Effect of Fluoxetine in Male and Female Rats Exposed to Single Prolonged Stress: A Behavioral, Biochemical, Molecular and Histological Study
Background: Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in patients with PTSD. Animal studies have indicated that chronic fluoxetine exposure leads to persistent behavioral changes and neuroplasticity in the hippocampal formation and cortex. Previous studies revealed that adult female rats respond differently to trauma from adult males. Here, we hav...