خنکدار طارسی, عباس
استادیار، گروه بیوشیمی- بیوفیزیک و ژنتیک، د انشکده پزشکی، د انشگاه علوم پزشکی مازندران، ساری، ایران
[ 1 ] - اثرات دگزامتازون بر آسیب‌های ایسکمی-ریپرفیوژن کبدی
Ischemia-reperfusion injuries (IRI) are the major causes of liver failure after various types of liver surgeries such as biopsy, transplantation, and tumor surgery. Its pathogenesis is multifactorial and complex that involves ATP depletion, hepatocyte edema, acidosis, oxidative stress, inflammation, and microcirculation defect which can eventually progress to liver cell death, systemic inflamma...
[ 2 ] - بررسی ارتباط بین میزان هوموسیستئین سرم با ایجاد آترواسکلروز در بیماران مبتلا به دیابت نوع 2
Background and purpose: Cardiovascular diseases are the leading causes of death in people with diabetes. These diseases occur earlier in diabetics than non-diabetics. Increased plasma homocysteine levels are among the factors that accelerate atherosclerosis in diabetic patients. Plasma homocysteine levels increase significantly in patients with atherosclerosis. Therefore, in this study, homocys...
[ 3 ] - اثرات سیلیبینین بر بیان ژن های نیتریک اکساید سنتاز طی ایسکمی-ریپرفیوژن گرم کبدی در رت های بالغ نر
Background and purpose: Ischemia-reperfusion injuries (I/RI) are the major causes of liver failure after various types of liver surgeries, particularly liver transplantation. Reactive oxygen species (ROS) are the major causes of such injuries, therefore, antioxidant therapy to attenuate hepatic lesions is preferred. We aimed to evaluate the effects of silibinin, a potent radical scavenger, on l...
[ 4 ] - Effect of dexamethasone on the endothelin-1 (ET-1) and endothelial nitric oxide synthase (eNOS) genes expression during hepatic warm ischemia/reperfusion in rat
Background: Hepatic ischemia/reperfusion injury (I/RI) is a multifactorial pathophysiologic process which can lead to liver damage and dysfunction. This study examined the protective effect of dexamethasone on the gene expression of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) and on the liver tissue damage during warm hepatic I/R. Materials and Methods: A total of 32 mal...
[ 5 ] - Melatonin Protective Effects against Liver Ischemia/Reperfusion Injury
Hepatic ischemia-reperfusion (I/R) is a common phenomenon during liver surgery, transplantation, infection and trauma which results in damage and necrosis of the hepatic tissue through different pathways. Mechanisms involved in I/R damage are very intricate and cover several aspects. Several factors are involved in I/R-induced damages; briefly, decrease in sinusoidal perfusion and ATP generatio...
[ 6 ] - The Effect of Dexamethasone on Expression of Inducible Nitric Oxide Synthase Gene During Liver Warm Ischemia-reperfusion in Rat
Background: Liver ischemia / reperfusion Injury (IRI) is one of the major causes of liver failure during various types of liver surgery, trauma and infections. The present study investigates the effect of dexsamethasone on the liver injury and inducible nitric oxide synthase gene expression during hepatic warm ischemia/reperfusion in rats. Materials and Methods: 24 male Wistar rats (200-250 g)...
[ 7 ] - The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review
Ischemia-reperfusion injuries (IRI) occur in different clinical conditions such as stroke, trauma, organ transplantation, and so on. Ischemia damages mainly arise from oxygen depletion in tissues. The lack of oxygen as the last acceptor of electron in the respiratory chain causes a decrease in ATP production and eventually leads to disruption of membrane transport, acidosis, cellular edema and ...
[ 8 ] - Effects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model
Objective(s): Liver ischemia-reperfusion injuries (I/RI) are typically the main causes of liver dysfunction after various types of liver surgery especially liver transplantation. Radical components are the major causes of such direct injuries. We aimed to determine the beneficial effects of silibinin, a potent radical scavenger on liver I/RI.Materials...