شکوهی, طاهره
استاد، گروه قارچ شناسی پزشکی، مرکز تحقیقات قارچ های تهاجمی، دانشگاه علوم پزشکی مازندران، ساری، ایران،محقق اصلی، مرکز تحقیقات قارچ های تهاجمی، دانشگاه علوم پزشکی مازندران، ساری، ایران
[ 1 ] - کریپتوکوکوس و کریپتوکوکوزیس: یافته های جدید راجع به پاتوژنز، تشخیص و استراتژی های درمانی در افراد با عفونت HIV
Cryptococcosis is a serious fungal infection in both huaman and animals caused by members of the Cryptococcus neoformans/ Cryptococcus gattii species complex. The main route of entry is respiratory tract. Meningitis is the most common clinical manifestation of cryptococcosis in immunocompromised patients and considered as one of AIDS defining illnesses. The known natural sources of the fungus...
[ 2 ] - شناسایی سریع پاتوژن‌های قارچی در نمونه‌های کشت خون بیماران سوختگی شدید با روش Panfungal PCR
Background and purpose: Fungemia is a significant cause of morbidity and mortality among immunocompromised patients such as severe burns. Due to low sensitivity and long turnaround time of the traditional biphasic BHI blood culture to detect fungemia we aimed to detect fungal elements in blood culture of these patients suspected with invasive fungal disease (IFDs) using panfungal PCR assay. ...
[ 3 ] - مروری بر کراتیت قارچی تشخیص، درمان با تاکید بر اپیدمیولوژی بیماری در ایران
Keratomycosis is the most important cause of ocular morbidity which is mainly occurred in field worker as an occupational disease. Fungal keratitis is caused by yeast and filamentous fungi. Aspergillus and Fusarium species are the most prevalent filamentous cause of keratomycosis. The most common yeast cause is Candida species especially C. albicans. In the last reports, trauma to the cornea...
[ 4 ] - مروری بر عفونت قارچی در بیماران سوختگی، تشخیص و درمان
Burn wound is a suitable environment for growth and reproduction of microorganisms. The tissue in the burn wounds is not live and do not have blood vessels so, polymorphonuclear antibodies and systemic antibiotics cannot diffuse into it. Thus, the condition of the wound is provided for the growth of bacteria and opportunistic fungi such as Candida, Mucor, Rhizopus, Penicillium, and Aspergillus....
[ 5 ] - تعیین توالی در چند ناحیه ژنی (MLST): یک روش تایپینگ مولکولی با قدرت تمایز بسیار بالا جهت شناسایی گونه‌های کاندیدا آلبیکنس در مطالعات اپیدمیولوژیکی
Candida spp. are ubiquitous yeasts commonly. Those are commensally and opportunist pathogens in humans. Candidiasis in immunocompromised patients and patients with severe underlying diseases or critical illnesses need aggressive diagnosis or treatment procedures. Candida albicans (C. albicans) is the most frequently isolated species. For prevention of nosocomial infections caused by C. albicans...
[ 6 ] - روش‌های تشخیصی بیماری‌های قارچی: از دوره کلاسیک تا عصر مولکولی
Human fungal diseases are largely a 20th and 21st century’s phenomenon. Due to use of corticosteroids and antibacterial drug, medical developmenta are associated with increased risk for number of fungal disease. These nosocomial developments in invasive mycosis were paralleled over the last two decades by the human immunodeficiency virus (HIV) pandemic, which has resulted in an even larger numb...
[ 7 ] - ارزیابی سطح سرمی آنتی ژن گالاکتومانان به منظور تشخیص آسپرژیلوزیس مهاجم در بیماران مبتلا به بدخیمی های خونی و گیرندگان پیوند مغز استخوان
Background and purpose: Invasive aspergillosis, is a serious fatal disease caused by fungal species of Aspergillus in patients with neutropenia, bone marrow transplant recipients, patients with blood disorders, chronic granulomatous disease, recipients of long-term steroids or antibiotics. Galactomannan antigen (GM) is a polysaccharide of Aspergillus present in the cell wall of Aspergillus spp....
[ 8 ] - ارزیابی کمی و بهینه سازی تشخیص DNA آسپرژیلوس فومیگاتوس در نمونه خون با استفاده از تکنیک Real time PCR
Background and purpose: Ïnvasive aspergillosis (ÏÂ) is a serious opportunistic infection caused by various species of Âspergillus in immnucompromissed individuals. Basically, rapid and early diagnosis prevents ÏÂ progression. The purpose of this study was to quantify and optimize detection of Âspergillus fumigatus DNÂ in blood samples using Real Time PÇR. Materials and methods: Five millil...
[ 9 ] - مروری بر مایستوما در ایران، با تاکید بر شمال کشور
Mycetomas are chronic granulomatous fungal diseases that involve cutaneous and subcutaneous tissues. Mycetomas are caused by fungi (Ëumycetoma) or fungus-like bacteria (Âctinomycetoma). The exogenous causative agents are geophilic organisms which introduced by traumas. We review 90 cases of mycetoma in Ïran from 1972 to 2009. There are rare reports of Mycetomas from Ïran with most cases (6...
[ 10 ] - بررسی 101 مورد اونیکومایکوزیس و عوامل مرتبط با آن در بیماران مراجعه کننده به درمانگاه پوست بیمارستان بوعلی سینا و کلینیک تخصصی طوبی ساری
Background and purpose: Onychomycosis is a nail fungal infection caused by various species of dermatophytes, yeasts and non-dermatophytic molds and represents about 30% of cutaneous mycotic infections. The goal of this study was to investigate the frequency of onychomycosis and its associated factors in patients referred to Boali Sina Hospital and Toba dermatology outpatient clinics, Sari. ...
[ 11 ] - تعیین گونه مالاسزیاهای جدا شده از بیماران مبتلا به پیتیر یازیس ورسیکالر و درماتیت سبوروئیک، با روش PCR-RFLP
Background and Purpose: Lipophilic yeast of the genus Malassezia are members of normal human cutaneous micro flora which are also associated with several skin diseases. It is strongly suspected that Malassezia species are responsible for pityriasis versicolor (PV), and seborrhoeic dermatitis (SD). Considering various sensitivities among Malassezia species to antifungal, accurate species identif...
[ 12 ] - Fungal peritonitis and cancer near the abdominal regions
Objective: Guidelines have recommended that structured programs to support fungal peritonitis in cancer patients should be introduced. The role of fungi in causing peritonitis is rare, but fungal peritonitis has high morbidity and mortality. The abdominal fullness may be secondary to the fungi accumulation of peritoneal fluid. The isolation of fungi, particularly Candida from peritoneal fluid s...
[ 13 ] - In vitro antitumor activity of patulin on cervical and colorectal cancer cell lines
Background and Purpose: Patulin is a mycotoxin produced by some molds,especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity. Materials and Methods: To determine the efficacy of patulin as a ther...
[ 14 ] - Clinical features, diagnosis, and outcomes of rhino-orbito-cerebral mucormycosis: A retrospective analysis
Background and Purpose: Rhino-orbito-cerebral mucormycosis (ROCM) is a rare disease with acute and fulminant manifestation. This infection is associated with high morbidity and mortality rates. Herein, we reviewed the manifestations, underlying conditions, medical treatments, and surgical interventions in ROCM patients admitted to a tertiary referral center in northern Iran over a seven-year pe...
[ 15 ] - In vitro activity of five antifungal agents against Candida albicans isolates, Sari, Iran
Background and Purpose: Candida albicans is the most common causative agent of candidiasis. Candidiasis management is dependent on the immune status of the host, severity of disease, and the choice of antifungal drug. Antifungals, specifically triazoles, are widely administered for the treatment of invasive fungal infections. Herein, we aimed to evaluate the in vitro susceptibility of C. alb...
[ 16 ] - In vitro activity of econazole in comparison with three common antifungal agents against clinical Candida strains isolated from superficial infections
Background and Purpose: Candida species are the most common organisms involved in superficial fungal infections, worldwide. Although econazole is among the most frequently used topical formulations for the treatment of candidiasis, no information is available regarding the susceptibility profiles of Candida species in Iran. Materials and Methods: In vitro susceptibility of 100 clinical Candida...
[ 17 ] - Detection of fungi by conventional methods and semi-nested PCR in patients with presumed fungal keratitis
Background and Purpose: Fungal keratitis is a suppurative, ulcerative, and sight-threatening infection of the cornea that sometimes leads to blindness. The aims of this study were: recuperating facilities for laboratory diagnosis, determining the causative microorganisms, and comparing conventional laboratory diagnostic tools and semi-nested PCR. Materials and Methods: Sampling was conducted in...
[ 18 ] - A real time PCR assay on blood for diagnosis of invasive candidiasis in immunocompromised patient
Background and Purpose: Invasive candidiasis (IC) is a significant cause of morbidity and mortality in patients with hematologic disorders and bone marrow transplant recipients. Rapid, specific and sensitive test for the timely accuracy in immunocompromised patients to reduce mortality rates and prevent IC progress is necessary. We established a real-time PCR assay on blood for the diagnosis an...
[ 19 ] - Quantification and Optimization of Candida albicans DNA in Blood Samples Using Real- Time PCR
Background: Candida albicans (C. albicans) is a major cause of candidaemia in people with impaired immunity. Blood culture is a “gold standard” for candidaemia detection but is time-consuming and relatively insensitive. We established a real-time PCR assay for C. albicans detection in blood by LightCycler PCR and melting curve analysis. Methods: Five milliliter blood samples from...
[ 20 ] - Catheter-related candidemia and identification of causative Candida species in patients with cardiovascular disorder
Background and Purpose: Catheter-related blood circulation infection is the most dangerous and serious side-effects of vascular catheters, which leads to the enhancement of the costs, mortality, and hospital stay duration, especially in the Intensive Care Unit. Regarding this, the aim of the current study was to identify the prevalence of catheter-induced candidemia in the Tehran Heart Center, ...
[ 21 ] - Effects of Acetic Acid Vaginal Gel on Vulvovaginal Candidiasis: A Double Blind Randomized Controlled Trial
Background and purpose: It is estimated that 70–75% of women experience one episode of vulvovaginal candidiasis (VVC) during childbearing age and 40-50% suffer from recurrent VVC. Because of the resistance of Candida species to certain drugs, such as azoles, physicians tend to use complementary or alternative medicine such as vinegar in treatment of VVC. The current study aimed to determine the...
[ 22 ] - Pediatric Catheters Infectivity and Identification of Candida Species Isolated from Hospitalized Patients in Mashhad Pediatric Hospital
Background and purpose: Invasive candidiasis in infants has high mortality rate and is often associated with colonization on medical devices such as catheters. Candida colonization is considered as a predisposing factor for Candida related infection. The aim of this study was to evaluate the rate of catheters infectivity by Candida species. Materials and methods: In this descriptive cross-sect...
[ 23 ] - Mucormycosis: A Lethal Phenomenon in COVID-19 Patients: A Review of Diagnostic and Therapeutic Approaches
Coronavirus disease 2019 (COVID-19) has seriously spread worldwide. One of the problems of COVID-19 patients is co-infection with other microbial infections such as fungal infections that are severely life-threatening. Mucormycosis, one of these opportunistic fungal diseases that is mistakenly known as black fungal disease, has been reported in Iran and the world. This non-systematic review is ...
Co-Authors