خداویسی, صادق

دانشگاه علوم پزشکی کردستان

[ 1 ] - بررسی آلودگی های قارچی حمام خوابگاه های دانشجویی دانشگاه علوم پزشکی کردستان در سال 1390

مقدمه: محیط های مرطوب با دمای مناسب مثل حمام و استخربه علت داشتن شرایط مناسب، مکان مهمی برای انتشار قارچ ها می باشند. بررسی عوامل قارچی فرصت طلب و پاتوژن مستقر در این اماکن می تواند کمک بسیارمؤثری در جهت رفع آلودگی یا کاهش میزان آن و در نتیجه پیشگیری از بروز عفونت های احتمالی باشد. لذا مطالعه حاضر با هدف بررسی آلودگی های قارچی حمام های خوابگاه های دانشجویی پسرانه و دخترانه دانشگاه علوم پزشکی ک...

[ 2 ] - Microsatellite Genotyping of Candida parapsilosis Clinical Isolates

Background and Purpose: Candida parapsilosis is a predominant species found in nosocomial infection, particularly in hospitalized patients. The molecular epidemiology of the clinical strains of this species has not been well studied. The present study was performed with the aim of investigating the microsatellite genotyping of Candida parapsilosis among the Iranian clinical isolates. Materials...

[ 3 ] - Effect of biogenic selenium nanoparticles on ERG11 and CDR1 gene expression in both fluconazole-resistant and -susceptible Candida albicans isolates

Background and Purpose: Candida albicans is the most common Candida species (spp.) isolated from fungal infections. Azole resistance in Candida species has been considerably increased in the last decades. Given the toxicity of the antimicrobial drugs, resistance to antifungal agents, and drug interactions, the identification of new antifungal agents seems essential. In this study, we assessed t...

[ 4 ] - Morphological changes and induction of antifungal resistance in Aspergillus fumigatus due to different CO2 levels

Background and Purpose: Aspergillosis is one of the most common opportunistic fungal infections in immunocompromised and neutropenic patients. Aspergillus fumigatus (A. fumigatus) is the most common causative agent of this infection. Due to variable CO2 concentrations that pathogens are exposed to during the infection process and to understand the role of CO2, we examined the effects of various...

[ 5 ] - Pseudohyphae formation in Candida glabrata due to CO2 exposure

Background and Purpose: Formation of pseudohyphae is considered a virulence factor in Candida species. Generally, Candida glabrata grows as budding yeast cells; however, reports illustrated that C. glabrata could form pseudohyphal cells in response to some stimuli. In this study, we provided insight into the ability of C. glabrata in forming pseudohyphal cells under different levels of carbon d...

[ 6 ] - Aspergillus colonization in patients with chronic obstructive pulmonary disease

Background and Purpose: Chronic obstructive pulmonary disease (COPD) has been recognized as a risk factor for invasive aspergillosis. Airway colonization by Aspergillus species is a common feature of chronic pulmonary diseases. Nowadays, the incidence of COPD has increased in critically ill patients. The aim of the present study was to isolate and identify Aspergillus colonies in the respirator...

[ 7 ] - Detection of galactomannan in bronchoalveolar lavage of the intensive care unit patients at risk for invasive aspergillosis

Background and Purpose: Invasive aspergillosis (IA) is one of the most common life-threatening fungal infections among the critically ill patients including intensive care unit (ICU) patients. Delayed diagnosis and therapy may lead to poor outcomes. Diagnosis may be facilitated by a test for molecular biomarkers, i.e. detection of galactomannan (GM) antigen based on enzyme immunoassay, which is...

[ 8 ] - Pneumocystis jirovecii colonization in Chronic Obstructive Pulmonary Disease (COPD)

Chronic obstructive pulmonary disease (COPD) is associated with a chronic inflammatory response in airways and lung parenchyma that results in significant morbidity and mortality worldwide. Cigarette smoking considered as an important risk factor plays a role in pathogenesis of disease. Pneumocystis jirovecii is an atypical opportunistic fungus that causes pneumonia in immunosuppressed host, al...

[ 9 ] - Molecular approaches to diagnosis of invasive aspergillosis what we know and what we do not know.

Invasive aspergillosis (IA) are a major complication in immunocompromized patients where can be serious and rapidly fatal. Early diagnosis and early appropriate antifungal treatment is important in reducing mortality and morbidity. But despite many efforts to develop detection methods, the diagnosis of IA still remains challenging and current conventional methods are limited for adequate diagno...

[ 10 ] - Candida auris, an Emerging Fungal Pathogen

The emerging pathogen “Candida auris” is attracting considerable international attention due to its rising reports, transmission through health professionals, high rate of treatment failure and resistance to multiple antifungal agents, particularly fluconazole. In spite of the global emergence of C. auris, epidemiological data and true prevalence of infections due to this organism are not clear...