Cyrus Jalili
Medical Biology Research Center, Kermanshah University of Medical Sciences,Kermanshah, Iran
[ 1 ] - The effects of crocin on the serum levels of sex hormone and NO in streptozotocin – induced diabetic rats.
Background and Aim: Diabetes can lead to reduced fertility in men by production of free radicals. Crocin (the effective component of saffron) with its antioxidant property can be effective in elimination of free radicals. We evaluated the effects of crocin on the reproductive parameters of the STZ –induced diabetic male Wistar rats. Materials and Method: Rats were made diabetic with...
[ 2 ] - اثر عصاره ی آبی ـ الکلی غازیاقی بر بافت پانکراس در موش صحرایی دیابتی شده با استرپتوزوتوسین
مقدمه: بیماری مزمن دیابت، سومین علت مرگ و میر در کشورهای در حال توسعه است. هایپرگلیسمی و استرس اکسیداتیو به عنوان اصلی‌ترین عوامل موثر در پاتوژنز دیابت شناخته شده‌اند؛ هم‌چنین سیستم آنتی‌اکسیدانی اولین خط دفاعی بدن در برابر استرس اکسیداتیو است. از طرفی، گیاه غازیاقی (Falcaria vulgaris) دارای ترکیباتی با خاصیت آنتی‌اکسیدانی و کاهنده‌ی گلوکز خون است. در این مطالعه، اثرات دزهای مختلف (50، 100، 15...
[ 3 ] - Kinetics of T cell response in the testes and CNS during experimental autoimmune encephalomyelitis: Simultaneous blood-brain and -testis barrier permeability?
Objective(s): Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are regarded as autoimmune diseases of the central nervous system (CNS). The CNS, testes, and eyes are immune privileged sites. It was initially presumed that ocular involvement in EAE and infertility in MS are neural-mediated. However, inflammatory molecules...
[ 4 ] - The effects of Petroselinum crispum extract on milk production parameters in female rats
Background and Aim: Use of medicinal plants is one of the methods to increase breast milk. Petroselinum crispum is a multipurpose herb in traditional medicine which contains essential amino acids, vitamins and numerous nutrients. This study aimed to determine the effects of Petroselinum crispum extract on milk production parameters in female rats. Material and Methods: In this experimental stud...
[ 5 ] - Crocin Reduces Oxidative Stress Produced by Busulfan Administration on Fertility of Male Rats
Background & Objective: Busulfan (BUS) as a drug for cancer treatment can produce free radicals. Crocin (CRO) is a potent antioxidant with beneficial effects. This study was designed to evaluate the effects of CRO against BUS-related damages to the male rats reproductive parameters. Materials & Methods: Forty-eight male rats were randomly assigned into 8 groups; Group 1 (normal control group) ...
[ 6 ] - Harmine recover kidney damage induced by morphine in male rats
Harmine is a harmal-derived alkaloid with antioxidant properties. The morphine produces free radicals and plays a key role in the pathogenesis of kidney disease. This study was designed to evaluate the effects of harmine against morphine- induced damage to the kidneys of rats. In this study, 64 male rats were randomly assigned to 8 groups: saline and morphine treated groups; harmine groups (5, ...
[ 7 ] - Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice
Objective Crocin, a carotenoid isolated from Crocus sativus L. (saffron), is a pharmacologically active component of saffron. Nicotine consumption can decrease fertility in males through induction of oxidative stress and DNA damage. The aim of this study is to determine the effects of crocin on reproductive parameter damages in male mice exposed to nicotine. MaterialsAndMethods In this experime...
[ 8 ] - Effects of Exposure to Aflatoxin G1 on the Plasma Biochemical Factors and Histopathological Properties of Renal Tissue in Mice
Background: Among aflatoxins, the subtype aflatoxin G1 is one of the most toxic, commonly found in cereals, legumes, dairy and non-alcoholic beers. Aflatoxins have been known as nephrotoxic compounds. In this study, changes in the expression of aquaporin-1, the histopathology of renal tissue and plasma biochemical factors after exposure to aflatoxin G1 were investigated in mice. Methods: Twent...
[ 9 ] - Investigating the Erα and Cyclin D1 Gene Expression Levels, Changes in SOD, NO, and MDA Levels, and Histopathology of Mice Testicular Tissue Treated with AFG1
Background and purpose: Previous studies have shown the adverse effects of aflatoxin G1 on testicular tissue and the process of spermatogenesis. The aim of this study was to investigate changes in the expression of Cyclin D1, the estrogen receptor ERα and the levels of nitric oxide (NO), superoxide dismutase (SOD), and malondialdehyde (MDA) in testicular tissue following exposure to AFG1. Mate...
[ 10 ] - Effects of Royal Jelly on Apoptosis and the Expression of Apoptotic Genes on Testicular Tissue in Male Balb/C Mice Treated with Daunorubicin
Background and purpose: Daunorubicin is an effective drug in chemotherapy, but its clinical use is limited due to serious side effects. Royal jelly as a natural compound obtained from bees can be helpful in preventing the damage caused by daunorubicin. The present study aimed to evaluate the effects of royal jelly on the number of apoptotic cells and the expression of genes involved in apoptos...
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