مسلمی, الهام
دانشگاه آزاد اسلامی واحد تهران شرق
[ 1 ] - بررسی میزان بیان ژن HE4 در بافت سرطان تخمدان
Introduction: Ovarian cancer is one of the common malignancies within women and the fifth cause of cancer death in women all over the world. Recent developments in Genomics and Proteomics technologies have led to the identification of unknown candidate markers for the diagnosis of ovarian cancer. Human epididymis protein 4 (HE4) has recently been supported to monitor the recurrence or the progr...
[ 2 ] - بررسی بیان گیرنده انسانی فاکتور رشد اپیدرمی 2 (HER2) در سلول‌های سرطانی افراد مبتلا به سرطان روده بزرگ
Background: Colorectal cancer is the fourth most common cancer in the world. It is the third largest risk factor for cancer individuals. The number of new cases is rising since 1975. Hyper activities of EGFR family have been reported in various cancers. The purpose of this study was to investigate the expression levels of HER2 in colorectal cancer and its possible association with advanced stag...
[ 3 ] - بررسی ژن HER3 به روش RT-PCR در نمونه‌های افراد مبتلا به سرطان پستان
چکیده مقدمه: امروزه سرطان پستان شایعترین سرطان در بین زنان و در عین حال مهمترین بیماریها در سراسر جهان میباشد. تحقیقات گستردهای در جهت پیشگیری و درمان سرطان صورت میگیرد. HER3 یکی از پروتئینهای متصل به غشا میباشد که توسط ژن ErbB3 کدگذاری میشود و تنها پس از هترودایمر شدن با دیگر اعضای خانواده میتواند فسفریله و فعال شود. هدف از این مطالعه بررسی بیانHER3 به عنوان یک فاکتور احتمالی دخیل ...
[ 4 ] - بیان ژن HER4 درنمونه های بلوک پارافینه بیماران مبتلا به سرطان پستان
Background: the breast cancer is the second cause of worldwide death. Understanding of molecular pathology of breast cancer can provide useful information about new treatment routes. HER4 gene considered as a molecular pre-prognostic marker in cancers recently. So the purpose of this research is studying of HER4 gene expression in breast cancer patients. Methods: in this study 70 samples of ...
[ 5 ] - بررسی بیان ژن یوبیکوئیتین D در انواع سرطان خون
Background:Research has shown that the expression of UBD (Ubiquitin D) is effective in causing cancer. UBD relationship between states with advanced stages of cancer cell differentiation and expression, which probably UBD involved in the progression of carcinogenesis. Overexpression of UBD is related to p53, which subsequently progress to cancer. The purpose of this study is evaluation of Ub...
[ 6 ] - بررسی بیان ژن های IL4، TNFα، TGFβ و IFNγ در تائید پلاریزاسیون ماکروفاژهای M1 و M2 حاصل از کشت مونوسیت های انسانی
background: Classical macrophages (M1) and alternative macrophages (M2) are responsible for various functions in order to maintain homeostasis. BCG vaccine and hydatid cyst fluid can be examples of stimulants which can cause M1and M2 macrophage polarization. Evaluating the expression of markers such as IFNγ and TNFα for M1 phenotype and TGFβ and IL4 for M2 phenotype is one of the confirmatory w...
[ 7 ] - بیان ژن KLK2 در سرطان پروستات
Background: Prostate cancer is one of the most common diseases that affect men. Although prostate cancer is not the fatal flaw in most cases, detection of effective factors for early diagnosis and treatment is essential. Research results have shown that the use of KLK2 plus PSA can be a good biomarker for diagnosing prostate cancer. During prostate cancer, expression of KLK2 gene increases whic...
[ 8 ] - نقش بیان ژن یوبیکوئیتین D (UBD) در پیش‌آگهی سرطان پستان
Background: Breast cancer is the most common non- skin cancer among women and it’s the second leading cause of cancer related death in women. Ubiquitin and ubiquitin like proteins are member of signal transduction pathways which have several cellular functions. It has shown that Ubiquitin like protein D (UBD) has accelerated the cancer progress. The aims of this study is evaluation of UBD gene ...
[ 9 ] - متیلاسیون اگزون 1، ژن CDKN2A در نمونه‌های بلوک پارافینه سرطان روده بزرگ
Background: The molecular studies indicate some of the genes in the promoter region itself, will undergo methylation. Methylation of CpG islands in the promoter region of that cause silence or reduced expression of genes involved in cell growth pathways, which are colorectal cancer causing agents. Detection of methylation status can be used as a marker for cancer diagnosis and prediction of dis...
[ 10 ] - PTEN Gene Expression and Its Association with rs10490920 SNP in Breast Cancer
Introduction: The PTEN gene, also known as MMAC1 or TEP1, is a tumor suppressor gene. One of the important polymorphisms of this gene is the rs10490920 SNP. The purpose of this study was to determine the PTEN gene expression and its relation to changes in rs10490920 polymorphism in breast cancer. Methods: In this study, 40 breast cancer patients and 10 healthy controls were considered. The expr...
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