الله توکلی, محمد
گروه فیزیولوژی و فارماکولوژی، دانشگاه علوم پزشکی رفسنجان
[ 1 ] - اثر متفورمین بر یادگیری لمسی و رفتار شبه اضطرابی در موش سوری اوارکتومی شده
Introduction: Estrogen regulates many processes in the brain such as synaptic formation, learning, and memory. Empirical evidence shows that there is a correlation among menopause, memory impairment, and anxiety due to Estrogen deficiency. In this study, we tested the effect of Metformin (Met) with antioxidant effect, which can improve the impairment of tactile learning and anxiety-like behavio...
[ 2 ] - بررسی اثر عصاره گیاه بومادران بر پیامد‌های ناشی از سکته مغزی در موش‌های صحرایی ماده بعد از برداشتن تخمدان‌ها
Introduction: Previous studies indicated estrogen as a protective factor in brain cells. In this study, effect of Yarrow extract (Achillea millefolium), containing a phytoestrogen, were examined on the consequences of stroke in the middle cerebral artery occlusion model in ovariectomized female rats. Methods: In the present study, 32 female Wistar rats weighing 200 to 250 g were randomly divi...
[ 3 ] - بررسی اثر هیپوترمی جنرال بر سکته مغزی مدل آمبولیک در موش صحرایی نر
Introduction: Hypothermia has neuroprotective effects in permanent or transient models of cerebral artery occlusion. In the current study, neuroprotective effect of general hypothermia in the embolic model of stroke, in which no study has been conducted to date. Methods: In this experimental study, twenty-four male Wistar rats (250 to 350 g) were divided into three groups as following: sha...
[ 4 ] - بررسی اثر عصاره گیاه پنج انگشت (Vitex agnus castus) بر یادگیری و حافظه در موش های صحرایی اوارکتومی شده
Background and purpose: Menopause is associated with the cessation of ovarian activities and hypoestrogenemia causing many complications including learning and memory disorders. Recent studies have shown that these cognitive disabilities are due to the diminished neuroprotective and neurotrophic effects of estrogen and accordingly, estrogen therapy may prevent or overcome them. Since estrogen t...
[ 5 ] - بررسی اثر تزریق تک‌دوز مرفین بر شاخص‌های خستگی عضلانی در موش‌های صحرایی نر
Background and Aim: Endogenous opioids and addictive opiate drugs change many body functions. . Previous studies have referred to the effects of morphine on smooth and pulmonary muscles ., but the effects of opioids on skeletal muscles is not known well. Thus, the current study aimed at assessing the effect of a single dose of morphine on muscle fatigue in male rats. Materials and Meth...
[ 6 ] - Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice
Objective(s): Ceftriaxone (Cef), a beta-lactam antibiotic, is accompanied by antioxidant and anti-inflammatory properties. It has been shown that Cef has beneficial effects on Alzheimer’s disease. In the current investigation, the effect of Cef in a mice model of aging was investigated. Materials and Methods: Forty male mice were equally...
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