نیکونهاد لطف آبادی, نرگس
دانشکده علوم، دانشگاه علم و هنر، یزد، ایران
[ 1 ] - جذب سلولی miRNA-101 و ارزیابی تأثیر آن بر القای سمیت سلولی و بیانیوبی کوئیتین لیگاز HECTH9 در سلولهای لوسمی میلوئیدی حاد (AML)
Introdution: In the present study, Lipofactamine 2000 was used as a cationic liposome for miR-101 transfection in order to investigate its cytotoxicity and its effect on the expression of ubiquitin ligase HECTH9 in acute myeloid leukemia cells (AML). Methods: MiR- 101 was transferred to KG-1 cells (myeloid cells) and HBMF-SPH (healthy bone marrow cells) using lipofectamine 2000 as a nano carri...
[ 2 ] - ارزیابی و مقایسه خواص فیزیکوشیمیایی، سمیت سلولی و توانایی بارگذاری miRNA درلیپوزوم‌‌های کاتیونی متفاوت به منظور کاربرد در ژن‌درمانی
Introduction: In the present study, various formulations of cationic liposomes were designed and prepared using different cationic lipids. It was performed to assess the physicochemical properties, miRNA loading ability and cellular toxicity rates of liposomes in order to use in gene therapy. Methods: Different cationic liposome formulations (F1-F4) containing various cationic lipids, DOTAP, D...
[ 3 ] - Evaluation of the Effect of Niosomal Nano-Carriers Containing Rosemary(Rosemary officinalis) Essential oil on Survival of KG-1 Cell Line of Acute Myeloid Leukemia
Introduction: The use of nanotechnology in drug delivery to the cells can somewhat address some of the problems involved in the delivery of herbal medicines, including non-targeting and high oxidizing features. Therefore,this study aimed to investigate the niosomal nano-carriers containing Rosmarinus officinalisessential oil to improve itsphysicochemical characteristics and increase its antitum...
[ 4 ] - Evaluation of the effect of methanolic extract of pomegranate peel on cytotoxicity induction and PDGF gene expression in cervical cancer (Hela cell line)
Background & Aim: Extract of pomegranate peel is a potential bioactive substance to combat cancer due to its rich cytotoxic components including polyphenols. This study aimed to identify phytochemical ingredients of pomegranate peel extract and assessed the level of their cytotoxicity on a cervical cancer cell line. In addition, the effect of this extract on expression of a key gene in the proc...
[ 5 ] - Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer
Aims Niosomes have been considered as carriers for targeted delivery of drugs in modern drug delivery systems. The Iranian Nepta (Nepta genus) has unique biological properties; thus, this plant was used in this study to prepare the optimized formulation of niosomes containing extract, and to evaluate its cytotoxicity. Methods & Materials Initially, the extract of Iranian Nepta (N. persica) was...
[ 6 ] - Effect of Rosemary Essential Oil on BIM Apoptotic Gene Expression in MCF 7 Breast Cancer Cell Line
Introduction: Breast cancer is the most common cancer among women and its treatment is associated with many side effects. Herbal medicine has fewer side effects than chemical drugs, so they are especially important in the treatment of many diseases. Rosemary plant has anti-cancer effects due to its antioxidant properties. The aim of this study was to evaluate the effect of Rosemary essential oi...
[ 7 ] - Investigating the antioxidant and anti-proliferative activity of Foeniculum vulgare seed essential oil on MCF-7 breast cancer cell line and A2780 ovarian cancer cell line
Background & aim: Due to the presence of high amounts of compounds with antioxidant and cytotoxic properties in Foeniculum vulgare mill seed essential oil, the aim of this study was to investigate the toxicity of Foeniculum vulgare mill seed essential oil on MCF-7 breast cancer cell line and A2780 ovarian cancer cell line and to investigate the antioxidant activity of the essential oil of this ...