Mohammad Reza Sam
Department of Cellular and Molecular Biotechnology, Institute of Biotechnology, Urmia University, Urmia, Iran
[ 1 ] - Treatment with 2-methyl- 3-pentyl-6-methoxyprodiginine isolated from serracia marcescens decreases cell viability and induces appoptosis in acute lymphoblaastic leukemia cells
Background & Aims: Acute lymphoblastic leukemia (ALL) is the most common malignancies in the world. Despite advances in treatment of patients with ALL, a subset of patients will have recurrent disease or refractory to chemotherapy and hematopoietic stem cell transplant. Consequently, assessment of the effectiveness of natural compounds with high efficacy and minimal side effects is warranted. I...
[ 2 ] - بیان مینی ژنهای فاکتور 9 انعقادی انسانی در سلولهای کلیه انسان
Background & aims: Hemophilia B is caused by either functional deficiency or lack of the human coagulation factor IX (hFIX). The current protein-based therapy with plasma-derived proteins increases, the risk of blood-borne pathogens transmission. Therefore, replacement therapy with recombinant hFIX (rhFIX) is an attractive alternative to plasma derived hFIX concentrates. In order to express and...
[ 3 ] - بررسی اثر ضد تکثیری متیل-3- پنتیل-6- متوکسی پرودیجینین در سلولهای سرطانی کبدی
Background & Aims: Hepatocellular carcinoma remains often refractory to classic therapies. Therefore, the search for new natural compounds with minimal toxicity is of particular interest in treatment of liver cancer. In this context, it has been shown that 2-methyl-3-pentyl-6-methoxyprodiginine isolated from cell wall of Serratia marcescens has powerful growth inhibitory effects against di...
[ 4 ] - مقایسۀ آثار ضدباکتریایی عصارۀ گلسنگ‌های Glypholecia scabra و Rhizoplaca melanophthalma بر برخی باکتری‌های استاندارد
مقدمه: در حال حاضر مقاومت ضدمیکروبی در میان باکتری‌ها و دیگر موجودات بیماری‌زا تهدید جدی برای مدیریت بیماری‌های عفونی است. جستجوی داروهای فعال زیستی جدید با منشأ طبیعی در گلسنگ‌ها موضوع بسیاری از گروه‌های تحقیقاتی است. مواد و روشها: عصارۀ استونی گلیفولسیا اسکابرا و ریزوپلاکا ملانوفتالما با استفاده از دستگاه سوکسوله تهیه شد. آثار ضدباکتریایی عصاره با استفاده از محیط کشت مولرهینتون آگار و آ...
[ 5 ] - Functions of the Heterologous Intron-Derived Fragments Intra and Extra Factor IX-cDNA Coding Region on the Human Factor IX Expression in HepG2 and Hek-293T Cells
Background: Human FIX (hFIX) gene transfer into hepatocytes has provided a novel approach for treatment of hemophilia B. To obtain an improved expression of hFIX, the functional hFIX-expressing plasmids with appropriate intron-derived fragments which facilitate transcription and promote an efficient 3′-end formation of mRNAs are required.Objectives: We ai...
[ 6 ] - حساسیت پرتویی سلولهای سرطان کولورکتال مقاوم به پرتو پس از تیمار با دوکوزاهگزانویک اسید و پرتو گاما
Background: Radiotherapy has been used to treat many types of cancers over the past years. Radiotherapy generates side effects on normal tissues. Radiosensitizer products provide decrease in tumor proliferation and reduce radiation dose in radiotherapy. Docosahexaenoic Acid (DHA) as an omega-3 polyunsaturated fatty acid has anti-proliferative effects on malignant cells. In this study, the effec...
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