رضائیان, لیلا

[ 1 ] - مهندسی آنزیم درمانی اوریکاز آسپرژیلوس فلاووس با استفاده از روش جهش‌زایی هدف‌دار

Background & Aims: As a therapeutic enzyme, Aspergillus flavus (uricase or; EC 1.7.3.3), is used for treatment of urate deposits, gout and nephropathy, hyperuricemia and tumor lysis syndrom (TLS). Despite desirable kinetic features, fragile stability of uricase limits its wide range applications. Therefore, several approaches have developed such as protein engineering and genetic manipulations ...