صریحی, عبدالرحمان
دانشگاه علوم پزشکی همدان
[ 1 ] - تاثیر مصرف مزمن فروزماید و تیامین بر قلب ایزوله موش های صحرایی نر
سابقه و هدف: دیورتیک‌ها با افزایش دفع تیامین سبب تضعیف قلبی می‌شوند. هدف مطالعه حاضر تعیین تاثیر مصرف مزمن تیامین و فروزماید به‌عنوان یکی از دیورتیک‌های پر مصرف بر فعالیت مکانیکی قلب به‌روش قلب جدا شده در موش‌های بزرگ آزمایشگاهی می‌باشد. مواد و روش‌ها: گروه‌های 8 تایی موش‌های صحرایی شامل، گروه کنترل (C)، گروه (FUR) که به‌مدت 53 روز فروزماید (mg/Kg 2) دریافت کردند و گروه (FUR+THI) که به‌مدت 53 ر...
[ 2 ] - Effects of Acute and Chronic Restraint Stress on Reinstatement of Extinguished Methamphetamine-induced Conditioned Place Preference in Rats
Introduction: Methamphetamine (METH) is a neurotoxic psychostimulant with highly addictive potential that leads to compulsive drug use and vulnerability to relapse. Environmental cues, such as drug exposure, peer influence, and social stress, are the powerful triggers of drug relapse. In this study, we tried to find out the effect of acute and chr...
[ 3 ] - Interaction between cannabinoid receptors and inhibition of L-type calcium channel on passive avoidance learning and memory in male rats
Introduction: There is currently a debate over the interaction between Ca2+ channels and cannabinoid system on learning and memory processing. In this study, we examined the effect of acute injection of cannabinoid agonist (Win- 55212-2) (Win) or antagonist (AM251), following chronic injection of verapamil, as a L-type Ca2+ channels blocker, on passive avoidance (PA) test in male Wistar rats...
[ 4 ] - Postnatal developmental alterations in the locus coeruleus neuronal fast excitatory postsynaptic currents mediated by ionotropic glutamate receptors of rat
Introduction: In the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal development of excitatory postsynaptic currents in locus coeruleus neurons. Methods: In this study, AMPA and NMDA receptor-mediated spontaneous synaptic currents in the neurons of locus coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks. ...
[ 5 ] - (S)- 3,5-Dihydroxyphenylglycine )an agonist for group I metabotropic glutamate receptors( induced synaptic potentiation at excitatory synapses on fast spiking GABAergic cells in visual cortex
Introduction: (S)- 3,5-Dihydroxyphenylglycine (DHPG) is an agonist for group I metabotropic glutamate receptors. DHPG-induced synaptic depression of excitatory synapses on hippocampal pyramidal neurons is well known model for synaptic plasticity studies. The aim of the present study was to examine the effects of DHPG superfusion on excitatory synapses on pyramidal and fast-spiking GABAergic cel...