کمکی, علیرضا
دانشگاه علوم پزشکی همدان
[ 1 ] - اثر مهار کننده تجزیه کانابینوئیدهای اندوژن در حضور وراپامیل بر پدیده های یادگیری و حافظه در موش بزرگ آزمایشگاهی
سابقه و هدف: اندوکانابینوئیدها یکی از سیستم های آندوژن هستند که حافظه و یادگیری را تحت تاثیر قرار میدهند. در مورد تداخل کانالهای کلسیمی نوع L و سیستم کانابینوئیدی در حافظه و یادگیری اختلاف نظر وجود دارد. در این مطالعه اثر تجویز حاد URB597 (مهارکننده تجزیه کانابینوئیدها) که بهدنبال تجویز مزمن وراپامیل (مهارکننده کانال کلسیمی) صورت گرفته است را بر تست یادگیری احترازی غیرفعال (Passive Avoidance...
[ 2 ] - Interaction Between the Cannabinoid and Vanilloid Systems on Anxiety in Male Rats
Introduction: Previous studies have shown that the cannabinoid system is involved in anxiety.In addition, transient receptor potential vanilloid type-1 (TRPV1) channels are new targets for the development of anxiolytics. The present study investigated the possible interaction between the cannabinoid and vanilloid systems on anxiety-like behavior in rats. Methods: Four different groups of male ...
[ 3 ] - Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus-Maze
Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is o...
[ 4 ] - Interaction between cannabinoid receptors and inhibition of L-type calcium channel on passive avoidance learning and memory in male rats
Introduction: There is currently a debate over the interaction between Ca2+ channels and cannabinoid system on learning and memory processing. In this study, we examined the effect of acute injection of cannabinoid agonist (Win- 55212-2) (Win) or antagonist (AM251), following chronic injection of verapamil, as a L-type Ca2+ channels blocker, on passive avoidance (PA) test in male Wistar rats...
[ 5 ] - Preconditioning Effect of High-Intensity Aerobic Training on Myocardial Ischemia-Reperfusion Injury and Beclin-1 Gene Expression in Rats
Purpose: Ischemia-Reperfusion (IR) injury is one of the most common cardiac disorders leading to irreversible heart damage. Many underlying mechanisms seem to be involved, among which disruption of cellular autophagy balance. Since physical training has a beneficial effect on the improvement of autophagy balance, it may have a cardioprotective effect against IR injury. This study investigates t...
[ 6 ] - Comparing the Impact of Long-Term Exposure to Extremely Low-Frequency Electromagnetic Fields With Diverse Values on Anxiety, Memory, Learning, and Β-Amyloid Deposition in Adult Rats
Background: Extremely low-frequency electromagnetic fields (ELF-EMFs) have gathered significant consideration for their possible pathogenicity. However, their effects on nervous system functions were not fully clarified. In this study, our aim was to assay the effect of ELF-EMFs with different intensity on memory, anxiety, antioxidant activity, beta amyloid (Aβ) deposition and microglia populat...
[ 7 ] - Effect of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields on β-amyloid Deposition and Microglia Cells in an Alzheimer Model in Rats
Background: Recently, researchers have considered extremely low-frequency electromagnetic fields (ELF-EMFs), as one of the non-invasive therapies, in the treatment of many severe neurological disorders, including Alzheimer Disease (AD). AD is a progressive neurodegenerative disease characterized by the deposition of amyloid plaques in the brain. However, the increase in microglial cells increas...
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