هاشمی, مهرداد
دانشگاه آزاد اسلامی، واحد پزشکی تهران
[ 1 ] - مطالعه تاثیر داروی پنتوکسی فیلین بر آپوپتوزیس کلیوی متعاقب آسیب ایسکمی- خونرسانی مجدد در موش صحرایی
سابقه و هدف: ایسکمی- خونرسانی مجدد باعث القاء مرگ سلولی و واکنش آماسی می‌گردد، که از مسایل بسیار مهم بالینی مرتبط با نارسایی حاد کلیوی و پیوند کلیه می‌باشد. در این مطالعه، تاثیر داروی پنتوکسی‌فیلین درعملکرد و آسیب سلولی کلیه موش صحرایی متعاقب آسیب ایسکمی- خونرسانی مجدد ارزیابی شد. روش بررسی: در این مطالعه تجربی، 20 سر موش صحرایی از نژاد ویستار جنس نر با میانگین وزنی 300-250 گرم انتخاب و سپس بط...
[ 2 ] - بررسی پتانسیل جهش‌زایی و فعالیت سیتوتوکسیک نانوذرات نقره بیوسنتزی
مقدمه: اطلاعات محدودی در رابطه با سمیت و آسیب ژنی نانوذرات موجود است. هدف از پژوهش حاضر بررسی اثر سیتوتوکسیک و پتانسیل جهش زایی نانوذرات نقره بیوسنتز شده به وسیله عصاره آبی گیاه فلوس (Cassia fistula) بود. روش بررسی: بدین منظور محلول نیترات نقره و عصاره آبی میوه گیاه فلوس به نسبت 9 به 1 مجاور شدند. پس از تغییر رنگ محلول، تولید نانوذرات نقره به وسیله روش‌های اسپکتروفتورمتری، پراش پرتوی ایکس، ...
[ 3 ] - Study of FGF14 gene expression and cancer progression in colorectal cancer tissue samples
Background: Colorectal cancer is one of the main causes of cancer death and the third most common malignant cancer worldwide. FGF14 is a member of the large family of fibroblast growth factors. These factors control a wide range of biological functions, including cell proliferation, survival, migration and differentiation that disturbing their expression can lead to cancer. The purpose of this ...
[ 4 ] - Conditioned Medium from Cultured Colorectal Cancer Cells Affects Peripheral Blood Mononuclear Cells Inflammatory Phenotype in Vitro
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Studies have indicated that immune cells and soluble factors play a key role in maintaining the balance between tumor-promoting inflammation and anti-tumor immunity. It has been shown that secreted cytokines from CRC cell lines could affect peripheral blood mononuclear cells (PBMCs), monocytes, and macrophages phenot...
[ 5 ] - Relationship between the expression of miR137 in the serum of patients with metastatic lung cancer
Background: Micro-Ribonocellic Acids (miRNA) are non-coding nucleic acids that are evolutionally protected and have a length of 24-20 nucleotides. MiRNAs control the expression of genes after transcription by mRNA degradation or translation inhibition. By blocking the oncogenic miRNAs and creating the necessary and functional miRNAs (tumor suppressor), these small regulatory RNAs can have thera...
[ 6 ] - The effects of chlorodiazepoxide on the Bax gene expression in CA1 pyramidal cells of the newborn rat hippocampus
Background: Most drugs used by pregnant women can pass through the placenta and expose embryos and developing embryos to teratogenic effects. Due to the increased cellular damage of Bax gene expression, the effect of cholorodiazepoxide use during pregnancy on Bax gene expression in the hippocampus of neonatal rats was investigated. Materials and methods: After confirmation of pregnancy in Wista...
[ 7 ] - Effects of Diamond nanoparticles on mitochondrial apoptosis pathway in rats with testicular ischemia / reperfusion.
Background and Aim: Testicular torsion is a urological emergency that leads to testicular tissue damage and infertility. In recent years, several studies have been conducted on the antioxidant properties of nanoparticles. The aim of this study was to investigate the effects of Diamond nanoparticles on the apoptosis in rats with testicular ischemia / reperfusion. Methods: 48 adult rats aged 20 ...
[ 8 ] - Simultaneous effects of curcumin and Fe3o4 nanoparticles on expression of Bad and Bclx genes in mitochondrial apoptosis in rats with testicular ischemia
Background and Aims: Testicular ischemia / reperfusion is one of the most serious urological emergencies that is generally identified in men, adolescents and infants. This causes damage to the testicles which, if misdiagnosed and treated improperly, can lead to infertility in men. In the present study, the effects of curcumin and Fe3O4 nanoparticles on the rate of apoptosis and expression of BA...