سادات ابراهیمی, سیداسماعیل
دانشیار، گروه شیمی دارویی، دانشکده داروسازی، دانشگاه علوم پزشکی تهران
[ 1 ] - تاثیر مهارکنندگی عصاره آبی الکلی موسیر (Allium hirtifolium Boiss.) بر روی رشد لیشمانیا اینفانتوم در شرایط آزمایشگاهی
مقدمه: اثرات ضد تک‌یاخته‌ای گیاهان جنس آلیوم مثل سیر و پیاز از قرن‌ها پیش ثابت شده است. هدف: بررسی اثر مهارکنندگی عصاره آبی الکلی موسیر بر رشد لیشمانیا اینفانتوم در شرایط آزمایشگاهی بررسی شد. روش بررسی: تاثیر غلظت‌های مختلف این عصاره (01/0، 05/0، 1/0 و 2/0 میلی‌گرم در میلی‌لیتر) در محیط کشت اشنایدر بر روی انگل در فاصله 7 روز بررسی شد. یافته‌ها: غلظت 01/0 تا 1/0 میلی‌گرم در میلی‌لیتر از عصار...
[ 2 ] - High-Performance Thin-Layer Chromatographic Fingerprints of Flavonoids and Phenol Carboxylic Acids for Standardization of Iranian Species of the Genus Crataegus L.
Eight samples of flowering tops from six species of the genus Crataegus L., commonly called Hawthorn, from different geographic locations of Iran were standardized according to German Pharmacopoeia monograph on Crataegi folium cum flore (hawthorn leaf with flower) by high-performance thin-layer chromatograph-ic (HPTLC) fingerprinting combining with digital scanni...
[ 3 ] - Novel 5-(nitrothiophene-2-yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity against promastigote stage of Leishmania major
In this study, a series of novel compounds based on 5-(5-nitrothiophene-2-yl)-1,3,4-thiadiazole possessing (het)aryl thio pendant at C-2 position of thiadiazole ring is developed and evaluated as antileishmanial agents using MTT colorimetric assay. 10 New compounds containing aryl and hetero aryl derivatives, started from thiophene-2-carbaldehyde in five steps, were synthesized in good to excel...
[ 4 ] - Novel 5-(nitrothiophene-2-yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity against promastigote stage of Leishmania major
In this study, a series of novel compounds based on 5-(5-nitrothiophene-2-yl)-1,3,4-thiadiazole possessing (het)aryl thio pendant at C-2 position of thiadiazole ring is developed and evaluated as antileishmanial agents using MTT colorimetric assay. 10 New compounds containing aryl and hetero aryl derivatives, started from thiophene-2-carbaldehyde in five steps, were synthesized in good to excel...
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