گودرزی, محمدتقی
استاد بیوشیمی بالینی -مرکز تحقیقات پزشکی مولکولی – دانشگاه علوم پزشکی همدان- همدان
[ 1 ] - بررسی برخی آنزیم‌های آنتی‌اکسیدان و شاخص‌های استرس اکسیداتیو در افراد دارای سندرم متابولیک در مقایسه با افراد سالم
Background and Objectives: Metabolic syndrome (MetS) is one of the most common diseases and a public health problem in most populations and predisposes to many metabolic disorders such as type 2 diabetes. Inflammatory processes and oxidative stress are the important factors in pathogenesis of MetS. Also, the effect of sex, race, age, nutrition and life style is very important in incidence of th...
[ 2 ] - بررسی ارتباط پلی‌مورفیسم Taq 1B در ژن کلستریل استرترانسفر پروتئین با پارامترهای سندرم متابولیک
Background & aims: Metabolic Syndrome (MetS) is a potential threatening factor for cardiovascular disorders and atherosclerosis which is accompanied by increase in plasma triglyceride, cholesterol, low density lipoproteins (LDL-c), fasting blood sugar (FBS) and low high density lipoproteins (HDL-c). Cholesteryl ester transfer protein (CETP) catalysis transfer of lipids and phospholipids betw...
[ 3 ] - نقش آدیپوکین‌ها در پاتوفیزیولوژی بیماری‌های قلبی-عروقی
Background: Cardiovascular Diseases (CVDs) are major causes of mortality worldwide. Obesity is regarded as an independent CVDs risk factor. In this article we focus on the role of adipokines which are involved in CVDs pathogenesis. Methods: The recent studies regarding the role of adipokines such as Leptin, Resistin, TNF-α, IL-6, MCP-1, Visfatin, Chemerin, Apelin, Omentin, Adipon...
[ 4 ] - Homocystein Level and Total Antioxidant Capacity in Chronic Obstructive Pulmonary Disease
Abstract Background and Objective: Oxidant-antioxidant imbalance plays a key role in pathogenesis of chronic obstructive pulmonary disease (COPD). This study aimed to evaluate homocystiene and total antioxidant capacity in COPD patients, compared to smoker and non-smoker healthy people. Material and Methods: We measured total antioxidant capacity with Cayman Kit, uric acid with Pars Azm...
[ 5 ] - Effects of Ascorbic Acid on Serum Level of Unconjugated Estriol and Its Relationship with Preterm Premature Rupture of Membrane: A Double-Blind Randomized Controlled Clinical Trial
Background: Vitamin C is a water-soluble antioxidant that not only stimulates and protects collagen synthesis but also plays an important role in maintaining cellular integrity in a normal pregnancy. This study surveyed the effects of ascorbic acid on the serum level of unconjugated estriol and the relationship between unconjugated estriol and preterm premature rupture of membrane (PPROM).Metho...
[ 6 ] - Effect of resveratrol on SNARE proteins expression and insulin resistance in skeletal muscle of diabetic rats
Objective(s): Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex proteins are involved in membrane trafficking. The expression of isoforms of SNAP-23, syntaxin-4, and VAMP-2 is significantly done in skeletal muscles; they control GLUT4 trafficking. It is believed that type 2 diabetes could be caused by the modifications in the express...
[ 7 ] - Evaluating the effect of arachidonic acid and eicosapentaenoic acid on induction of adipogenesis in human adipose-derived stem cells
Objective(s): Adipose tissue is one of the most important endocrine organs that liberates many metabolic mediators such as hormones, cytokines, and chemokines. Different types of fatty acids have key roles in adipogenesis. The aim of this study was to evaluate the effects of two essential fatty acids, including Arachidonic acid (AA) and Eicosapentaenoic acid (EPA), on ...