Fuping Liu

[ 1 ] - Potassium carbonate as a base for cycloalkylation of diethyl malonate and ethyl cyanoacetate in solid-liquid two phase systems

The cycloalkylation of diethyl malonate and ethyl cyanoacetate with alkyl dihalide was investigated by using comminuted potassium carbonate as a base and toluene as a solvent in the presence of hexadecyltrimethylammonium bromide (HTMAB) as a phase-transfer catalyst, which provided a conventional procedure with the advantage of short reaction period and high product yield. The factors influencin...