Abbas Mohammadpour
Pharmaceutical Research Center, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
[ 1 ] - Association of rs12108497 (Caspase 3 Gene) Polymorphism in Gastric Cancer Patients in Sari
Gastric cancer is the fourth most common cause of malignancy death in the world, which also has a high prevalence in Iran. Caspase 3 gene is considered one of the major genes related to gastric cancer. The present study aimed to investigate the relationship between rs12108497 polymorphism of Caspase 3 gene. Due to the fundamental role of caspases, we have considered an SNP of Caspase 3 (common ...
[ 2 ] - Investigating the Distribution of ERCC2 (rs13181) Gene Polymorphism in Gastric Cancer Patients in Mazandaran: A Case-control Study
Background and objectives: Gastric cancer is one of the most common cancers of the gastrointestinal tract in the world, which also has a high prevalence in Iran. ERCC2 gene is considered one of the major genes related to gastric cancer. The present study aimed to investigate the relationship between rs13181 polymorphism of ERCC2 gene. The polymorphism in the promoter region of ERCC2 gene can af...
[ 3 ] - ارزیابی مقایسه ای ماست سل ها بین کارسینوم سلول سنگفرشی دهان و پوست
سابقه و هدف: ماست سل ها یکی از سلولهای دفاعی سیستم ایمنی هستند اما گزارش شده که ماست سل ها ممکن است به تهاجم تومورکمک نمایند. با توجه به رفتار تهاجمی متفاوت Oral squamous cell carcinoma= OSCC دهانی با پوستی (CSCC=Cutaneous squamous cell carcinoma)، هدف از این مطالعه مقایسه تعداد ماست سلها بین OSCC و CSCC برای درک نقش آنها در رفتار بیولوژیک متفاوت این دو تومور می باشد. مواد و روش‌ها: در این مط...
[ 4 ] - Evaluation of a modified salt-out method for DNA extraction from whole blood lymphocytes: A simple and economical method for gene polymorphism
Extraction of high-quality and-quantity DNA is a fundamental requirement for genetic research. It is very important to address the use of DNA extraction methods that are simple and cost-effective in gene polymorphism with large number of samples. This study was designed to investigate the optimal DNA extraction from lymphocytic cells by salt-out method. In this study, 200 blood samples of the t...
[ 5 ] - Association between XRCC1 (rs1799782) Gene Polymorphism and Oral squamous cell carcinoma
Background and purpose: Oral squamous cell carcinoma (OSCC) is the most common tumor of the head and neck. XRCC1 is a DNA repair gene and there are controversies about the association between XRCC1 gene polymorphism (RS1799782) in pathogenesis and susceptibility to OSCC. The purpose of this study was to investigate the association between XRCC1 (rs1799782) gene polymorphism and its dominant all...
[ 6 ] - Doxorubicin and Doxorubicin-loaded Nanoliposome Triggers Hepatocyte Cells Senescence through Accumulation of Inflammatory Factors and Activation of P53
Background and purpose: Induction of cellular senescence is indicative of new strategy to prevent abnormal proliferation of cancer cells. Doxorubicin (DOX) is gaining attention for its neoplasia suppressive and inhibitory properties, but its clinical utility is limited due to irreversible effects on non-target cells/tissues. In this way, nanoliposomal structures were developed in drug delivery ...
[ 7 ] - Association between rs2119882 (MT1A) Melatonin Receptor Polymorphism and Childhood Leukemia Using RFlP-PCR Method
Background and purpose: Melatonin is a well-known neuroendocrine reproductive hormone-based hormone that has an important role in the circadian clock system and has potent antioxidant properties. New studies have also suggested an antitumor role for melatonin. The role of melatonin receptors is proven in many cancers, including colon and breast cancers, but so far, no study has been performed i...
[ 8 ] - Protective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid
Background and purpose: It is well established that valproic acid (VPA) is teratogenic associated with oxidative stress in humans and in all animal species tested. In this study, considering the chemical composition of catechins, we investigated its protective effect on the survival of PC12 nerve cells exposed to valproic acid. Materials and methods: The protective effects of epicatechin (EC)...
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