Leila Zarei
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
[ 1 ] - Protective effects of vitamin E and Cornus mas fruit extract on methotrexate-induced cytotoxicity in sperms of adult mice
This study was aimed to assess the protective effects of Cornus mas fruit extract (CMFE) and vitamin E (Vit E) on sperm quality parameters in the methotrexate (MTX)-treated mice. Forty-eight young adult male mice (8-12 weeks) were randomly divided into six groups including control and test groups. The control group received normal saline orally , and the test groups were treated MTX (2...
[ 2 ] - اثرات باکتری بیفیدوباکتریوم بیفیدوم بر تکثیر رده سلولی 562K
زمینه و هدف: در مطالعات گذشته به اثرات مفید مصرف خوراکی باکتریهای پروبیوتیک در درمان برخی از سرطانهای گوارشی اشاره شده است. هدف از این مطالعه بررسی اثرات مستقیم عصاره دیواره سلولی باکتری بیفیدوباکتریوم بیفیدوم بر تکثیر رده سلولی سرطانی اریترومیلوئیدی انسانی 562K است. مواد و روشها: پس از کشت باکتریها و آماده‌سازی فراکشن دیواره سلولی، رﻗﺖﻫﺎی 1000، 2000، 4000 و 8000 ﻣﻴﻜﺮوﮔﺮم در میلی‌لیتر از د...
[ 3 ] - Evaluation of Pharmacological Effective Concentrations of Aspirin with/without Radiotherapy on MCF-7 Breast Cancer Cell Line
Objective- The studies have been shown that aspirin, an anti-inflammatory agent, could reduce occurrence of different cancers. The aim of the present study was to evaluate pharmacological effective concentrations of aspirin with/without radiotherapy on growth rate of MCF-7 breast cancer cell line Design- Experimental Study Animals- The MCF-7 breast cancer cell line from rats P...
[ 4 ] - The effect of CoQ10 on Testicular Tissue in Rats Treating with Busulfan: Sperm Quality and Histological Changes.
Objective: Busulfan(Bus) is a chemotherapy drug that is widely used for cancer treatment. The protective effect of CoQ10 evaluated on testis and sperm parameters after busulfan treatment. Design: Experimental Study Animals: Thirty tow adult male Wistar rats Procedures: In this experimental study 32 adult male Wistar rats have randomly divided into four groups: Control group ...
[ 5 ] - In vivo assessment of anti-tumor activity of Methyl 2'-Methyl-1,3-dioxo-1,1',2',3,5',6',7',7a'-octahydrospiro[indene-2,3'-pyrrolizidine]-2' carboxylate (6) on 7,12 dimethylbenz(a) anthracene-induced mammary tumors in rat
Objective- Breast cancer is one of the most serious problems in oncology. Alkaloids pyrrolizidine are widely found in nature and exhibited versatile biological activities. The aim of the present study was to assess anti-tumor activity of methyl 1,3-dioxo-1,1',2',3,5',6',7',7a'-octahydrospiro[indene-2,3'-pyrrolizidine]-2'-carboxylate (6) on 7,12 dimethylbenz(a) anthracene (DMBA)-induced mammary ...
[ 6 ] - Effect of Chitosan/Propolis Biodegradable Film on Full-Thickness Wound Healing in Rats
Objective - The objective of the present study was to assess effect of Propolis in combination with chitosan biofilm on excisional wounds. Design- Experimental Study.Animals- Male healthy Wistar rats.Procedures- Sixty-four rats were randomized into four groups of 16 rats each. Group I: Animals with wounds treated with 0.9% saline solution. Group II: Animals with wounds were dr...
[ 7 ] - Co-administration of retinoic acid and atorvastatin mitigates high-fat diet induced renal damage in rats
Obesity causes many problems such as cardiovascular and chronic kidney diseases. The aim of this study was to evaluate the efficacy of retinoic acid and atorvastatin co-administration in kidneys protection against high-fat diet induced damage. Twenty-five male Wistar rats (200.00 ± 20.00 g) were divided into five groups: 1) Control (standard diet), 2) High-fat diet (cholesterol 1.00%, 75 days),...
[ 8 ] - Protective effects of Cornus Mas fruit extract on methotrexate-induced alterations in mice testicular tissue: Evidences for histochemical and histomorphometrical changes in an animal model study
Methotrexate (MTX) as a chemotherapeutic agent, has adverse effects on reproductive organs by enhancing oxidative stress. In this study, the protective effects of Cornus mas fruit extract (CMFE) against MTX side effects were evaluated. Forty-eight mature male NMRI mice were divided into six groups: group 1 (control) received 0.10 mL per day of normal saline intraperitoneally (IP), grou...
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