Davood Mehrabani
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
[ 1 ] - Busulfan induced azoospermia: Stereological evaluation of testes in rat
The aim of the present study was stereological evaluation of testes of azoospermic animal model using busulfan in rat. Three groups of male adult rats were used in this study. The first group was injected by single dose of busulfan (10 mg kg-1) and their testes were removed on day 35 post injection. The second group received double doses of busulfan with 21 days interval and their te...
[ 2 ] - اثرآب انار بر پروفایل لیپیدی در موشهای صحرایی نر بالغ دیابتی شده با استرپتوزوسین
افزایش میزان چربیهای خون یکی از شایعترین تظاهرات در بیماری دیابت میباشد که باعث تشدید عوارض این بیماری میگردد. آب انار مادهای مغذی با مصارف پزشکی میباشد. مطالعه حاضر با هدف بررسی اثرات آب انار بر میزان تریگلیسرید، کلسترول، LDL و HDL در موشهای صحرایی نر بالغ سالم و دیابتی شده انجام گرفت. در این پژوهش 90 سر موش صحرایی نر بالغ با وزن 220-200 گرم به گروههای کنترل، شاهد، تجربی دیابتی و غیرد...
[ 3 ] - The Effect of Lithospermum officinale, Silver Sulfadiazine and Alpha Ointments in Healing of Burn Wound Injuries in Rat
BACKGROUND Burn is the most devastating condition in emergency medicine leading to chronic disabilities. This study aimed to compare the effect of Lithospermum officinale, silver sulfadiazine and alpha ointments on healing of burn wounds in rat. METHODS Ninety-five rats were divided into 5 groups. Group 1 just underwent burn injury, and groups 2-5 received alpha ointment, silver sulfadiaz...
[ 4 ] - The Effect of Grape Seed Oil Enema with or without Sesame Oil in Acetic Acid Induced Ulcerative Colitis of Rats
BACKGROUND Inflammatory bowel diseases contain two digestive system diseases, ulcerative colitis (UC) and Crohn’s disease with unclear causes. The aim of present study was to investigate the therapeutic effects of administration of the Sesame oil (SO) and grape seed oil (GSO) as enema route in rats suffering from experimental acetic acid induced UC. METHODS Eighty male rats were ...
[ 5 ] - Cloning: A Review on Bioethics, Legal, Jurisprudence and Regenerative Issues in Iran
In recent years, the cloning technology has remarkably developed Iran, but unfortunately, the required legal framework has not been created to support and protect such developments yet. This legal gap may lead to abuse of scientific researches to obtain illegal benefits and to undermine the intellectual property rights of scientists and researchers. Thus to prevent such consequences, the attemp...
[ 6 ] - Regenerative Potential of Endometrial Stem Cells: A Mini Review
Recent findings in stem cell biology have opened a new window in regenerative medicine. The endometrium possesses mesenchymal stem cells (MSCs) called endometrial stem cells (EnSCs) having specific regenerative properties linked to adult stem cells. They contribute in tissue remodeling and engineering and were shown to have immuno-modulating effects. Many clinical trials were undertaken to asce...
[ 7 ] - اثر محیط کشت حاصل از سلولهای بنیادی مزانشیمیمغز استخوان در درمان ناباروری آزواسپرمیک القاء شده به وسیله بوسولفان در موش بالب– سی
چکیده زمینه و هدف: تجویز داروهای شیمی‌درمانی در بیماران مبتلا به سرطان می‌تواند زمینه‌ساز ناباروری باشد، لذا این مطالعه با هدف بررسی اثر محیط استفاده شده در کشت سلولهای بنیادی مزانشیمیمغز استخوان(سیکریتا) در درمان ناباروری آزواسپرمیک القاء شده به وسیله بوسولفان در موش بالب‌ـ سی انجام گردید. روش بررسی: در این مطالعه تجربی، 18 سر موش سوری از نژاد بالب - سی به صورت تصادفی به سه گروه کنترل، آز...
[ 8 ] - بررسی اثر ترمیمی پیوند سلول های بنیادی مزانشیمی مغز استخوان در مهارتهای حرکتی ضایعات نخاعی حاد در موش
زمنیه و هدف: آسیب نخاعی حاد نوعی آسیب مخرب است که نقص های حرکتی و حسی را بدنبال دارد و موجب کاهش کیفیت و امید به زندگی در بیماران می شود. پیوند سلول های بنیادی می تواند یکی از استراتژی های درمانی محسوب شود. مغز استخوان منبع غنی از سلول های بنیادی بوده که قادر به تمایز به انواع سلول ها می باشد. در این مطالعه، سلول های بنیادی مغز استخوان در مدل ضایعه ی نخاعی در موش پیوند زده شده و عملکرد حرکتی جه...
[ 9 ] - مقایسه اثر درمانی سلولهای بنیادی مزانشیمی مغز استخوان و محیط کشت مایع حاصل از آن در درمان سائیدگی ایجاد شده در مفصل زانوی خوکچه هندی
زمینه و هدف: استئوآرتریت یک بیماری شایع و دردناک مفصلی با علت نامعلوم می باشد. این بیماری با سن در ارتباط بوده و بیشتر در سنین میانسالی و بالاتر دیده می‌شود. در مهندسی بافت استفاده از سلول های بنیادی به دلیل داشتن توانایی بالا در تکثیر و تمایز، افق نوید بخشی را در ترمیم آسیب های وارده به ارگان ها و بافت ها از جمله غضروف به وجود آورده است. هدف از انجام این مطالعه بررسی اثر ترمیمی سلول های بنیادی...
[ 10 ] - Epidemiology of Inflammatory Bowel Diseases in Iran and Asia; A Mini Review
The prevalence of inflammatory bowel diseases (IBDs) is set to stabilize in Western Europe and North America, as opposed to its increasing trend in developing countries in Asia. The epidemiology of IBDs in areas where the incidence and prevalence are relatively low provides an opportunity for researchers to determine the unknown aspects of them. In this review article, the PubMed and MEDLINE da...
[ 11 ] - Impacts of Bone Marrow Stem Cells on Caspase-3 Levels after Spinal Cord Injury in Mice
Spinal cord injury (SCI) is a drastic disability that leads to spinal cord impairment. This study sought to determine the effects of bone marrow stem cells (BMSCs) on caspase-3 levels after acute SCI in mice. Forty-two mice were randomly divided into 3 groups: control (2 subcategories), subjected to no intervention; sham (3 subcategories), subjected to acute SCI; and experimental (2 subcategori...
[ 12 ] - Growth Kinetics, Characterization, and Plasticity of Human Menstrual Blood Stem Cells
One of the readily available sources of mesenchymal stem cells (MSCs) is menstrual blood-derived stem cells (Men-SCs), which exhibit characteristics similar to other types of MSCs. This study was performed to determine the growth kinetics, plasticity, and characterization of Men-SCs in women. During spring 2014 in the southern Iranian city of Shiraz, menstrual blood (5 mL) was obtained from 10 ...
[ 13 ] - Survival of Dental Pulp Stem Cells: The effect of Soymilk and Milk
Background & Objectives: Dental pulp stem cells (DPSCs) are alternate source of mesenchymal stem cells. Subsequent to tooth avulsion and fracture, DPSCs can play a prominent role in tissue regeneration. This study was conducted to evaluate the effect of soymilk and milk on survival of dental pulp stem cells. Materials & Methods: DPSCs were isolated from 16 freshly extracted incisors of 5 rabbi...
[ 14 ] - The Effect of Vitrification on Follicular Morphology of Ovarian Rat
Background & Objective: Some efforts have been made for keeping cryopreservation of gametes and embryos safe, including new vitrification methods of the ovary. This study evaluates the effect of ethylene glycole vitrification on follicular morphology of ovarian rat. Materials & Methods: Eighty ovaries belonging to 40 rats are divided into 2 groups. Twenty five ovaries are control group, 25 the ...
[ 15 ] - P-45: Xenotransplantation of Mouse Ovaries into Pseudopregnant Rat Uteri
Background Xenotransplantation of ovary can help individuals who may be at sterility risk after chemotherapy or radiotherapy of diseases such as cancer. Moreover, this technique can be used to preserve fertility of valuable animal species. The aim of the present study was to preserve balb/c mice ovarian tissue by xenotransplantation into uterus of rat that is immune suppressed. MaterialsAndMeth...
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