Mehdi Sadeghi
National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran 14155-6346, Iran.
[ 1 ] - Clustering of Short Read Sequences for de novo Transcriptome Assembly
Given the importance of transcriptome analysis in various biological studies and considering thevast amount of whole transcriptome sequencing data, it seems necessary to develop analgorithm to assemble transcriptome data. In this study we propose an algorithm fortranscriptome assembly in the absence of a reference genome. First, the contiguous sequencesare generated using de Bruijn graph with d...
[ 2 ] - مقایسه کارایی یک تابع انرژی دانش‌پایه و یک تابع نیروی دانش‌پایه در نمره‌دهی کمپلکس‌های پروتئین-پروتئین
تابع نیروی دانش‌پایه نوعی از توابع نمره‌دهی می‌باشد که از آن در زمینه تشخیص فولد پروتئین‌ها با موفقیت قابل توجهی استفاده شده است. ما در این مطالعه کارایی نوعی تابع انرژی دانش‌پایه و تابع نیروی هم ارز آن را در تشخیص کمپلکس‌های درست پروتئین-پروتئین از کمپلکس‌های نادرست، با یکدیگر مقایسه کردیم. مقدار نیروی کل که از یک جزء کمپلکس (گیرنده/لیگاند) بر جزء دیگر وارد می‌شود به عنوان معیار پایداری کمپلکس...
[ 3 ] - In Silico Perspectives on the Prediction of the PLP’s Epitopes involved in Multiple Sclerosis
Background: Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS). The main cause of the MS is yet to be revealed, but the most probable theory is based on the molecular mimicry that concludes some infections in the activation of T cells against brain auto-antigens that initiate the disease cascade.Objectives: The Purpose of this research is the...
[ 4 ] - Helix Segment Assignment in Proteins Using Fuzzy Logic
The automatic assignment of protein secondary structure from three dimensional coordinates is an essential step in the characterization of protein structure. <span style="font...
[ 5 ] - Modeling gene regulatory networks: Classical models, optimal perturbation for identification of network
Deep understanding of molecular biology has allowed emergence of new technologies like DNA decryption. On the other hand, advancements of molecular biology have made manipulation of genetic systems simpler than ever; this promises extraordinary progress in biological, medical and biotechnological applications. This is not an unrealistic goal since genes which are regulated by gene regulatory ...