Sassan Rezaie
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran | Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - Green synthesis of silver nanoparticles: The reasons for and against Aspergillus parasiticus
Objective(s): The enzymatic activity of fungi has recently inspired the scientists with re-explore the fungi as potential biofactories rather than the causing agents of humans and plants infections. In very recent years, fungi are considered as worthy, applicable and available candidates for synthesis of smaller gold, silver and other nano-sized particles. Materials and Methods: A standard str...
[ 2 ] - Identification and antifungal susceptibility pattern of Candida species isolated from patients with nosocomial candiduria
Introduction: Nosocomial candiduria could be due to cystitis, pyelonephritis, or fungusball in the urinary tract system. Several reports have shown candidemia and upper urinarytract involvement as the complications of candiduria. The aim of this study was to assessnosocomial candiduria; identify Candida isolates and determine their drug susceptibilitypattern. Materials and Methods: Urine sample...
[ 3 ] - Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis
Background: Candida parapsilosis is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms. Methods: The antifungal susceptibility of 120 clinical C. parapsilosis isolates was examined. The changes in the ...
[ 4 ] - Down-Regulation of sidB Gene by Use of RNA Interference in Aspergillus nidulans
Background: Introduction of the RNA interference (RNAi) machinery has guided the researchers to discover the function of essential vital or virulence factor genes in the microorganisms such as fungi. In the filamentous fungus Aspergillus nidulans, the gene sidB plays an essential role in septation, conidiation and vegetative hyphal growth. In the present study, we benefited from the RNAi strate...
[ 5 ] - Down-Regulation of the ALS3 Gene as a Consequent Effect of RNA-Mediated Silencing of the EFG1 Gene in Candida albicans
Background: The most important virulence factor which plays a central role in Candida albicans pathogenesis is the ability of this yeast to alternate between unicellular yeast and filamentous hyphal forms. Efg1 protein is thought to be the main positive regulating transcription factor, which is responsible for regulating hyphal-specific gene expression under most conditions. ALS3 is one of the ...
[ 6 ] - In Vitro Ovicidal Activity of Nematophagous Fungus Paecilomyces lilacinus on the Eggs of Parasitic Helminths
Introduction: The nematophagus fungi have been suggested as an alternative way to eliminate the zoonotic helminths eggs from the environment. In the present study, we evaluated the ovicidal activity of a fungus, Paecilomyces lilacinus, recovered from a compost soil, on the eggs of parasitic helminths under in vitro condition. Methods: Water suspension of the soil samples collected from differen...
[ 7 ] - بررسی وجود ژن کد کننده اسکوالن اپواکسیداز در قارچ درماتوفیت ترایکوفایتون ویولاسئوم
سابقه و هدف: ترایکوفایتون ویولاسئوم یک قارچ درماتوفیت است که پوست، ناخن و موی انسان را مورد تهاجم قرار می دهد. اما مطالعات کمی بر روی زیست شناسی مولکولی این قارچ انجام شده است. این مطالعه با هدف بررسی حضور ژن کد کننده اسکوالن اپواکسیداز در قارچ ترایکوفایتون ویولاسئوم انجام شده است. مواد و روش ها: این مطالعه به صورت مقطعی بر روی قارچ ترایکوفایتون ویولاسئوم جدا شده از بیماران مراجعه کننده به بخش...
[ 8 ] - Effect of biogenic selenium nanoparticles on ERG11 and CDR1 gene expression in both fluconazole-resistant and -susceptible Candida albicans isolates
Background and Purpose: Candida albicans is the most common Candida species (spp.) isolated from fungal infections. Azole resistance in Candida species has been considerably increased in the last decades. Given the toxicity of the antimicrobial drugs, resistance to antifungal agents, and drug interactions, the identification of new antifungal agents seems essential. In this study, we assessed t...
[ 9 ] - Morphological changes and induction of antifungal resistance in Aspergillus fumigatus due to different CO2 levels
Background and Purpose: Aspergillosis is one of the most common opportunistic fungal infections in immunocompromised and neutropenic patients. Aspergillus fumigatus (A. fumigatus) is the most common causative agent of this infection. Due to variable CO2 concentrations that pathogens are exposed to during the infection process and to understand the role of CO2, we examined the effects of various...
[ 10 ] - First case of superficial infection due to Naganishia albida (formerly Cryptococcus albidus) in Iran: A review of the literature
Background and Purpose: Naganishia albida (formerly Cryptococcus albidus) is a non-neoformans cryptococcal species rarely isolated as a human pathogen. Case report: Herein, we present the case of a 26-year-old Iranian man with a superficial cutaneous lesion in the axilla. The initial treatment for pityriasis versicolor by clotrimazole was unsuccessful. We performed skin sampling based on the s...
[ 11 ] - Pseudohyphae formation in Candida glabrata due to CO2 exposure
Background and Purpose: Formation of pseudohyphae is considered a virulence factor in Candida species. Generally, Candida glabrata grows as budding yeast cells; however, reports illustrated that C. glabrata could form pseudohyphal cells in response to some stimuli. In this study, we provided insight into the ability of C. glabrata in forming pseudohyphal cells under different levels of carbon d...
[ 12 ] - Effects of thiamine on growth, aflatoxin production, and aflr gene expression in A. parasiticus
Background and Purpose: Mycotoxins are secondary fungal metabolites with a very high diversity that are produced by some species of Aspergillus which frequently leads to contaminate food and agricultural products. Recently, elimination of aflatoxin contamination in food and feed has been considered by scientists worldwide. Although, the antibacterial and antifungal effects of vitamins as natura...
[ 13 ] - تاثیر دیکلوفناک سدیم بر میزان رشد و تغییرات مورفولوژیک آسپرژیلوس فومیگاتوس و کاوش اثر آن بر روی پروتئین سیدروفور با بررسی بیان ژن sidB
Background and Aim: Considering the increasing drug resistance to Aspergillus fumigatus, search for genes involved in its pathogenicity and identifying alternative antifungal drugs is of utmost importance. The aim of this study was to determine the effects of diclofenac sodium on the growth and sidB gene expression in Aspergillus fumigatus. Materials and Methods: In this study, Aspergillu...
[ 14 ] - اثر ضد قارچی صمغ ون (Pistacia atlantica var.kurdica) بر قارچ آسپرژیلوس پارازیتیکوس
Background and Aim: Aspergillus arasiticus species can contaminate agricultural products both on the farm and in storage in tropical regions. In recent years much research has been conducted on extracts of, and chemical compounds derived from, plants to be used potentially to reduce growth of toxin-producing microorganisms. Not much information is available in this area, so this study was condu...
[ 15 ] - تأثیر اشعه‌ی فرابنفشB بر برخی خصوصیات فیزیولوژیک و قدرت بیماریزایی در کاندیدا آلبیکنس
Background and Aim: Candida albicans, the most common human fungal commensal pathogen, is a normal member of the human microbiota which can colonize the oral cavity, vagina and gastrointestinal tract. This opportunistic pathogen can cause diseases ranging from mucosal infections to systemic mycoses, depending on the vulnerability and weakness of the immune system of the host. In addition, i...
[ 16 ] - بررسی وجود ژن کد کننده اسکوالن اپواکسیداز در قارچ درماتوفیت ترایکوفایتون ویولاسئوم
سابقه و هدف: ترایکوفایتون ویولاسئوم یک قارچ درماتوفیت است که پوست، ناخن و موی انسان را مورد تهاجم قرار می دهد. اما مطالعات کمی بر روی زیست شناسی مولکولی این قارچ انجام شده است. این مطالعه با هدف بررسی حضور ژن کد کننده اسکوالن اپواکسیداز در قارچ ترایکوفایتون ویولاسئوم انجام شده است. مواد و روش ها: این مطالعه به صورت مقطعی بر روی قارچ ترایکوفایتون ویولاسئوم جدا شده از بیماران مراجعه کننده به بخش...
[ 17 ] - Molecular Investigation of Diversity Normal Yeast Flora in Cow Raw Milk Industrial Farms of Tehran Province and Alborz
Background and Objective: Milk is a completely rich and complex environment suitable for different microorganisms including bacteria and Fungi. The majority of studies were conducted on milk-bacterial flora and aflatoxin-contaminations in dairy products; however, despite the importance of yeasts in usage as starter in the dairy industries and their effect on the taste of dairy products as well ...
[ 18 ] - A Comparative Study on Level of erg11 Gene Expression in Non-albicans Candida Strains Isolated from Patients and Raw Milk
Nowadays, non-albicans Candida are common in human pathogens, and some of these cases were found in milk in the present study. Thanks to its various minerals and vitamins, milk is a good food source for humans and an ideal environment for the growth of microorganisms, including bacteria and fungi. Also, it is an important product in the agricultural sector. Materials and Methods: In the presen...
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