Sepideh Arbabi Bidgoli
Department of Toxicology and Pharmacology, Islamic Azad Universtiy, Pharmaceutical Sciences Branch (IAUPS), Tehran, Iran|Pharmaceutical Sciences Research Center, Islamic Azad University, Pharmaceutical Sciences Branch (IAUPS), Tehran, Iran
[ 1 ] - Electrospun polymeric nanofibers for transdermal drug delivery
Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...
[ 2 ] - سمیت عضوی عصاره هیدروالکلی چای کوهی ( Stachys Lavandulifolia Vahl) در موش سوری ماده
سابقه و هدف: علی‌رغم رویش گیاه چای کوهی در بسیاری از نقاط ایران و کشورهای منطقه و اثرات آن در کنترل درد، التهاب، اضطراب و دیس‌منوره، اطلاعات منسجمی در خصوص سمیت این گیاه وجود ندارد. اخیرا طی مطالعه‌ای سمیت حاد و تحت حاد عصاره گیاه، حداکثر دوز قابل تحمل و پتانسیل سمیت را با تعیین فاکتور No Observable Adverse Effect Level مشخص نمودیم، اما تاثیرات هیستوپاتولوژیکی آن در الگوی مصرف تحت مزمن هدف مط...
[ 4 ] - Genotoxicity assessment of Elaeagnus angustifolia L. fruit extract (senjed) nanocapsule by in vitro and in vivo methods
Background: Although initial studies on Elaeagnus Angustifolia L. Fruit Extract (Senjed) Nanocapsule showed its efficacy in osteoporosis in rat model as well as its significant role in elevating the serum calcium levels, there is no study on its possible genotixic potentials which is necessary for developing all nanopharmaceuticals. Objective: This study aimed to evaluate the genotoxicity of Se...
[ 5 ] - Acute and Repeated Dose Toxicity Assessment of Kelussia Odoratissima Mozaff Essential Oil in Female Rat
Background: We aimed in this study to evaluate the acute and repeated dose toxicity of Kelussia odoratissima Mozaff (Kelussia) identified as a rare medicinal plant species which grows in western parts of Iran with potential nutraceutical applications. Materials and Methods: To determine the clinical, hematological, biochemical, necropsy and histopathological effects of the herb’s essential oil...
[ 6 ] - Toxicity assessment of high fructose corn syrup-55: a repeated dose oral toxicity study in uterus and ovaries of female rats
Background: High-fructose corn syrup-55 (HFCS-55) is a common sweetener in the food industry. Recently, we have investigated and published the effects of uncontrolled long-term oral ingestion of 55-HFCS compared to sucrose on primary ovarian insufficiency in female rats. This study aimed to compare the effects of short-term controlled HFCS-55 administration with sucrose and its possible effects...