Daryoush Shahbazi-Gahrouei
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
[ 1 ] - Targeted detection of the cancer cells using the anti-CD24 bio modified PEGylated gold nanoparticles: the application of CD24 as a vital cancer biomarker
Objective(s): The central role of molecular imaging modalities in cancer management is an undeniable fact that could help to diagnose cancer tumors in early stages. The main aim of this study is to prepare a novel targeted molecular imaging nanoprobe of CD24-PEGylated Au NPs to improve the ability of Computed tomography scanning (CT scan) outputs for both in vitro and in vivo detection of breas...
[ 2 ] - Gadolinium-Diethylenetriaminepenta-Acetic acid Conjugated with Monoclonal Antibody C595 as New Magnetic Resonance Imaging Contrast Agents for Breast Cancer (MCF-7) Detection
Background: The monoclonal antibody, C595, against breast cancer cell line was conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (Gd-cDTPAa) to produce Gd-DTPA-C595 and used as specific breast cancer cell line (MCF-7) contrast agents in magnetic resonance imaging (MRI). Methods: After incubation of breast cancer cell line (MCF-7), with different contrast agents (G...
[ 3 ] - Radiation cancer risk from doses to newborn infants hospitalized in neonatal intensive care units in children hospitals of Isfahan province
Background: This study aimed to investigate dose area product (DAP), effective dose, and radiation risk in newborn infants hospitalized in neonatal intensive care units in Isfahan and Kashan. Materials and Methods: During a period of six months, DAP for chest X-ray examinations for newborn infants hospitalized in NICUs of five special hospitals including Beheshti (in Kashan), Al-Zahra, Imam Hos...
[ 4 ] - Detection of breast cancer using non-invasive X-ray diffraction technique of hair: A preliminary study
Background: An early diagnosis of breast cancer relates directly to an accurate treatment plan and strategy. Early detection of breast cancer before its development would be a significant reduction of morbidity and mortality rates. The aim of this preliminary study is to investigate the sensitivity of Wide Angle X-ray diffraction (WAXRD) method on women hair samples of healthy and breast cancer...
[ 5 ] - Determination of organ doses in radioiodine therapy using medical internal radiation dosimetry (MIRD) method
Background: Radioiodine therapy has proven to be an effective method in the treatment of patients with differentiated thyroid carcinoma after thyroidectomy. The scope of this study is to describe a method to obtain the dose of organs using medical internal radiation dosimetry (MIRD) method. At the end, the results of MIRD calculations were compared with thermoluminescent dosimeter (TLD...
[ 6 ] - Dosimetric characteristics of 137Cs sources used in after loading Selectron system by Monte Carlo method
Background: For an effective treatment planning in brachytherapy, it is necessary to know the accurate source dosimetric information such as air kerma strength, exposure rate constant, dose rate constant and redial dose distribution. The usual method to determine these factors is thermo luminescent dosimeter (TLD) dosimetry. Nowadays, another more accurate method is known to be the Monte Carlo ...
[ 7 ] - Design and Fabrication of a Four-Dimensional Respiratory Phantom for Studying Tumor Movement in Radiotherapy with Magnetic Resonance Imaging
Introduction: In radiation therapy, determining the location of the tumor accurately during irradiation is one of the most important requirements. However, lung tumors are not fixed in a single location and move during irradiation due to respiratory motion. Due to limitations in assessing such movements, using a lung phantom can be useful and operational for their fast, easy an...
[ 8 ] - Effect of Material and Wall Thickness Buildup Caps on the Head ScatterFactor Measurements in Irregular Fields Shielded by Cerrobend
Introduction: The head scatter factor (Sc) is important to measurements radiation beam and beam modeling of treatment planning systems used for advanced radiation therapy techniques. This study aimed to investigate the design of a mini-phantom to measurement variations in collimator Sc in the presence of shielding blocks for shaping the beam using different field sizes. <str...
[ 9 ] - AS1411 Aptamer Conjugated Gold Nanoclusters as a Targeted Radiosensitizer for Megavoltage Radiation Therapy of 4T1 Breast Cancer Cells
Introduction: In the present study, AS1411 aptamer conjugated gold nanoclusters (GNCs) have been introduced as a targeted radiosensitizer for enhancing megavoltage radiation therapy efficacy. RT has identified as an effective therapeutic modality for many different types of solid tumors. However, equal radiation beams absorption by tumor and surrounding healthy tissues is still...
[ 10 ] - Synthesis and Cytotoxicity Assessment of Gold-coated Magnetic Iron Oxide Nanoparticles
Introduction: One class of magnetic nanoparticles is magnetic iron oxide nanoparticles (MIONs) which has been widely offered due to of their many advantages. Owing to the extensive application of MIONs in biomedicine, before they can be used in vivo, their cytotoxicity have to be investigated. Therefore, there is an urgent need for understanding the potential risks associated with MIONs.Materia...
[ 11 ] - Effects of RF-EMF Exposure from GSM Mobile Phones on Proliferation Rate of Human Adipose-derived Stem Cells: An In-vitro Study
Background:As the use of mobile phones is increasing, public concern about the harmful effects of radiation emitted by these devices is also growing. In addition, protection questions and biological effects are among growing concerns which have remained largely unanswered. Stem cells are useful models to assess the effects of radiofrequency electromagnetic fields (RF-EMF) on other cell lines. S...
[ 12 ] - Rapid Delivery of Gold Nanoparticles into Colon Cancer HT-29 Cells by Electroporation: In-vitro Study
Background: Electroporation has become a routine technique for rapid drug delivery for the treatment of cancer. Because of its simplicity and wide range of application, it has been applied for the transfer of gold-nanoparticles and can facilitate entry into target cancer cells. Objective: The aim of this study is finding optimal conditions in order to obtain high GNPs- uptake and cell via...