Mosayeb Rostamian
Department of Biology, Faculty of Basic Sciences, Imam Hussein University, Tehran, Iran.
[ 1 ] - The effect of pH on recombinant C-terminal domain of Botulinum Neurotoxin type E (rBoNT/E-HCC)
Recombinant proteins are tending to be the most favorable vaccine-candidates against botulism. Recombinant Carboxy-terminal of botulinum neurotoxin serotype E (rBoNT/E-HCC) has been introduced as an efficient vaccine against botulism type E. In this report, we made an effort to investigate the effect of different pH on protein structure to assess if rBoNT/E-HCC could be used as a vaccine for or...
[ 2 ] - مطالعه ترمودینامیکی پایانه کربوکسیل نوروتوکسین بوتولینوم تیپ E با روش طیف سنجی دورنگ نمایی دورانی
به‌منظور پیشگیری از سندروم بوتولیسم، به‌تازگی محققین به استفاده از واکسن‌های نوترکیب توجه خاصی نشان داده‌اند. یکی از این واکسن-ها، پروتئین نوترکیب حاوی 93 اسید آمینه انتهای کربوکسیلی نوروتوکسین بوتولینوم تیپ E (rBoNT/E-HCC) است. در این تحقیق پس از بیان و تخلیصrBoNT/E-HCC، به بررسی اثر pH بر این پروتئین توسط طیف‌سنجی دورنگ نمایی دورانی (Circular Dichroism, CD) پرداخته شده و به دنبال آن مطالعات ...
[ 3 ] - Route of Infection Affects Pathogenicity of Leishmania major in BALB/c Mice
Introduction: The term Leishmaniasis applies to a group of parasitic diseases caused by the genus Leishmania. Route of infection is one of the variables that have been reported to influence the immune responses as well as the disease outcome in experimental models of leishmaniasis. This research aims to study the effect of route of infection on the pathogenicity of Leishmania major in BALB/c mi...
[ 4 ] - Prevalence of Extended-Spectrum Beta-Lactamase in Gram Negative Bacteria Isolated from Kermanshah Medical Centers: A Systematic Review and Meta-Analysis
Background and Aim: Nosocomial infections caused by gram-negative bacteria are among the most important health-threatening challenges of the current century, particularly following the emergence and spreading of antibiotic-resistance strains. Extended-spectrum beta-lactamase (ESBL), one of the most important antibiotic resistance mechanisms, is spreading worldwide. Surveillance and gathering da...