Mohammad Reza Asadi Karam
Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran
[ 1 ] - Cloning and determination of biochemical properties of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli into pET28a vector
Urinary tract infections are one of the most common infectious diseases that lead to significant health problems in the world. Urinary tract infections are referred to any infection in any part of the renal system. Uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella are main organisms that are involved in these infections. After identifying same protective and conserved virulence ...
[ 2 ] - Distribution of Genes Encoding Iron Uptake Systems among the Escherichia coli Isolates from Diarrheal Patients of Iran
Introduction: Diarrheagenic Escherichia coli (DEC) including enteropathogenic (EPEC), enteroaggregative (EAEC), enterotoxigenic (ETEC), and shiga toxin producing E. coli are among the most common agents of diarrhea. There are various classes of iron uptake receptors, but there is not much data on the presence of these iron receptors in DEC isolates. The present study aimed to evaluate the prese...
[ 3 ] - Detection of Metallo-β-Lactamases (MBLs) Producing Pseudomonas aeruginosa Isolates in Tehran Hospitals, Iran
Introduction: The strains of Pseudomonas aeruginosa are known as an opportunistic pathogen that can cause infections in humans and animals. Metallo-β-lactamases (MBLs) are the most significant factors of resistance to carbapenem antibiotics in these bacteria. This study was designed to identify the MBLs producing P. aeruginosa isolates in three hospitals of Tehran, Iran. Methods: Tota...
[ 4 ] - بررسی فنوتیپی و ژنوتیپی مقاومت به آنتی‌بیوتیک‌های کینولون در ایزوله‌های بالینی اشریشیاکلی جدا شده از عفونت ادراری افراد بستری در بیمارستان های شهر تهران در سال 1396
Background & Aim: Antibiotic resistance to quinolones as a therapeutic agent of urinary tract infection in increasing in the world. Thus, this study was designed to evaluate the resistance to quinolone antibiotics in Escherichia coli isolated from urinary tract infection of hospitalized patients in Tehran, Iran in 2017. Methods: In the present study, 150 E. coli isolates was collected from uri...
[ 5 ] - بررسی حضور اینتگرون ها و ارزیابی ارتباط آنها با مقاومت آنتیبیوتیکی در بین ایزوله های اشریشیاکلی جدا شده از عفونت دستگاه ادراری بیماران مراجعه کننده به بیمارستانهای شهر تهران
اهداف: سویه‌های اشریشیاکلی به عنوان مهمترین عامل عفونت دستگاه ادراری هستند. اینتگرون‌ها به عنوان یکی از عوامل انتقال مقاومت آنتیبیوتیکی می‌باشند. هدف از مطالعه حاضر شناسایی اینتگرون‌ها و ارتباط آنها با مقاومت آنتیبیوتیکی در ایزوله‌های اشریشیاکلی بود. مواد و روش‌ها: تعداد 150 ایزوله اشریشیاکلی از ادرار بیماران با عفونت دستگاه ادراری در بیمارستانهای شهر تهران، (ایران) جمع آوری شد. ارزیابی مقا...
[ 6 ] - بررسی فراوانی و توالی نوکلئوتیدی ژنهای کد کننده فاکتورهای جذب آهن در ایزوله های پروتئوس میرابیلیس جدا شده از بیماران با عفونت ادراری در ایران
Background: Iron adsorption factors are among the most important virulence factors of P. mirabilis causing urinary tract infections. The aim of the present study was the evaluation of the frequency and nucleotide sequence of genes encoding the iron adsorption genes in Proteus mirabilis isolated from patients with urinary tract infections. Materials and Methods: In total, 100 P. mirabilis isola...
[ 7 ] - Construction and assessment of the immunogenicity and bactericidal activity of fusion protein porin A from Neisseria meningitidis serogroups A and B admixed with OMV adjuvant as a novel vaccine candidate
Objective(s): The porins A and B and also outer membrane vesicles (OMVs) of Neisseria meningitidis are used for vaccine purposes. In the present study, we aimed to design a new vaccine candidate based on a fusion of PorA of serogroups A and B of N. meningitidis admixed with OMV and evaluate it in an animal model.Materials and Methods: Af...
[ 8 ] - Evaluation of the effect of IDR-1018 antimicrobial peptide and chitosan nanoparticles on imipenem susceptible and resistant Pseudomonas aeruginosa isolated from patients with urinary tract infections from ICU
Background and aim: Excessive use of antibiotics has significantly increased resistance to common antibiotics in the treatment of urinary tract infections. In the present study, antimicrobial efficacy of chitosan nanoparticles and peptide IDR-1018 was evaluated against P. aeruginosa isolates. Methods: In the present study, 20 resistant and 20 sensitive P. aeruginosa isolates to imipenem were ...
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