Malek Soleimani Mehranjani
Professor of Histology and Embryology, Department of Biology, Faculty of Science, Arak University, Arak, Iran
[ 1 ] - Curcumin Protects Mice Testicular Tissue against the Adverse Effects of Sodium Arsenite: A Stereological Study
Background & Aims: Sodium arsenite, an environmental pollutant, produces free radicals with harmful effects on the reproductive system. The aim of this study was to investigate the effect of curcumin, as a strong antioxidant, on the testis tissue and spermatogenic cell population in mice treated with sodium arsenite. Methods: In this experimental study, A...
[ 2 ] - Stereological Study of the Protective Role of Curcumin on Histological Changes of Seminal Vesicle in Mice Following Treatment with Sodium Arsenite
Background & Aims: Sodium arsenite causes oxidative stress and endocrine disorders in the reproductive system. The aim was to investigate the protective role of curcumin as an antioxidant on the seminal vesicle tissue in adult mice treated with sodium arsenite. Materials & Methods: Adult male Naval Medical Research Institute (NMRI) mice were randomly divided into 5 groups (six mice per group) ...
[ 3 ] - نقش حفاظتی ویتامین E در جلوگیری از تغییرات نامطلوب بیسفنولA بر بافت بیضه موش صحرایی: یک ارزیابی استریولوژیک
Introdution: Bisphenol A (BPA) as an environmental pollutant has estrogenic effects and can induce oxidative stress in the testis tissue. The aim of the present study was to investigate the role of vitamin E (Vit E), as a strong antioxidant, on the adverse effect of BPA on adult rat testis tissue. Methods: Male rats (220±15g) were divided into 4 groups (n=6/each): control, Bisphenol A (...
[ 4 ] - بررسی آزمایشگاهی اثر ویتامین E بر قدرت زیستی، تغییرات مورفولوژیک و القاء تمایز استئوژنیک در سلول‌های بنیادی مزانشیمی مغزاستخوان رت بالغ
Introduction: Vitamin E as a strong antioxidant plays an important role in inhibiting free radicals. Therefore, this study aimed to investigate the effect of vitamin E on the viability, morphology and osteogenic differentiation in bone marrow mesenchymal stem cells of an adult rat. Methods: The bone marrow mesenchymal stem cells were extracted using the flashing-out method. At the end of the t...
[ 5 ] - اثر روغن سیاه‌دانه بر بافت کلیه موش نر پس از سمیت القاء شده با بیس‌فنل‌آ: یک مطالعه استریولوژیک
زمینه و هدف : بیس‌فنل‌آ (Bisphenol A: BPA) یک ماده تخریب کننده اندوکرینی است و به‌عنوان یک آلاینده زیست محیطی از طریق تولید رادیکال آزاد موجب تخریب بافتی می‌گردد. این مطالعه به منظور تعیین اثر روغن سیاه دانه در برابر سمیت ناشی از بیس‌فنل‌آ بر بافت کلیه موش نر نژاد NMRI به روش استریولوژیک انجام شد. روش بررسی : در این مطالعه تجربی 24 سر موش نر بالغ نژادNMRI با میانگین وزنی ٣±٣٢ گرم به‌طور تصادفی ...
[ 6 ] - اثر حفاظتی ویتامین E بر سمیت القاء شده توسط پارانونایل‌فنل بر بافت بیضه موش صحرایی بالغ
زمینه و هدف : نونایل فنل یک آلاینده زیست محیطی با خاصیت استروژنی ضعیف است که موجب استرس اکسیداتیو در بافت‌های مختلف از جمله بیضه می‌گردد. این مطالعه به منظور تعیین اثر ویتامینE به عنوان یک آنتی‌اکسیدان قوی بر بافت بیضه موش‌های صحرایی تیمار شده با پارانونایل‌فنل انجام شد. روش بررسی : در این مطالعه تجربی 24 سر موش صحرایی نر نژاد ویستار به طور تصادفی به 4 گروه شش تایی کنترل، vitamin E 100 mg/kg/d...
[ 7 ] - بررسی تاثیر ویتامین E بر تمایز آزمایشگاهی سلول‌های بنیادی مزانشیم مغز استخوان رت بالغ به استئوبلاست طی تیمار همزمان با سدیم آرسنیت
Introduction & Objective: Sodium arsenite disturbs the differentiation of adult rat bone marrow mesenchymal stem cells (rMSCs) to Osteoblast through oxidative stress. We aimed to investigate the preventive effect of vitamin E, a strong antioxidant, in sodium arsenite toxicity on rMSCs differentiation to osteoblast. Materials & Methods: rMSCs were cultured in Dulbecco’s Modified Eagles Medium...
[ 8 ] - اثر مت‌فورمین بر بیان ژن Pdx-1 طی تکامل پانکراس موش
مقدمه: مت‌فورمین یک داروی خوراکی است که برای درمان دیابت نوع 2 مورد استفاده قرار می‌‌گیرد. داروی مت‌فورمین آنالوگ (GLP-1) است و مشخص شده است که GLP-1 سبب القای بیان ژن‌های Pancreatic duodenal homeobox-1 (Pdx-1)، انسولین و گلوکز ترانسپورتر-2 (Glut-2) می‌گردد. پژوهش حاضر به بررسی اثر مت‌فورمین بر تنظیم عملکرد سلول‌های بتا از طریق اثر بر بیان ژن‌های Pdx-1، انسولین و Glut-2 می‌پردازد. مواد و روش‌ها...
[ 9 ] - The effect of long term treatment of lowest effective dose of para-nonylphenol on viability, morphology and proliferation of rat bone marrow mesenchymal stem cells
Introduction: In this study, the effect of para-nonylphenol as an environmental pollutant on viability, morphology and proliferation of bone marrow mesenchymal stem cells was investigated. Methods: Bone marrow mesenchymal stem cells of rat were treated with the 0.5, 1, 2.5, 3.5 and 5 μM of paranonylphenol for a period of 21 days, then the viability of the cells were estimated using trypan bl...
[ 10 ] - تعیین ناهنجاری های عددی و ساختاری در مجموعه کروموزوم های موش های صحرایی مبتلا به سرطان پوست و بررسی مناطق متناظر آن ها در کروموزوم های انسان
زمینه و هدف: القاء سرطان پوست در موش های صحرایی نژاد SD ایجاد تومورهایی را می نماید که از نظر فیزیولوژیکی و شیمیایی شباهت های زیادی با تومورهای پوستی در انسان دارد. لذا این مطالعه با هدف تعیین ناهنجاری های عددی و ساختاری در مجموعه کروموزوم های موش های صحرایی مبتلا به سرطان پوست و بررسی مناطق متناظر آن ها در کروموزوم های انسانی انجام شد. روش بررسی: در این مطالعه تجربی mg 5/2 ماده ی کارسینوژنیک...
[ 11 ] - The Effect of Pentoxiphylin on Histological Changes of Testis and Spermatogenesis Indexes in Mouse Treated With Dexamethasone
Background and Objectives: Dexamethasone is one of the common drugs, which is used in the human severe allergies and can cause defect in the reproductive system by inducing oxidative stress. In this study, the effect of pentoxifylline as a potent antioxidant, was investigated on changes in testicular tissue and spermatogenesis indices in mice treated with dexamethasone. Methods: In this expe...
[ 12 ] - Study The Protective Effect of Quercetin on Testis Histological Changes and Spermatogenesis Indexes in Adult Mice Following Treatment with Dexamethasone
Introdution: Dexamethasone is used in inflammatory disease, leukemia and nausea, which increases the oxygen free radicals in the testis as a consequence. The aim of this study was to study the protective effect of Quercetin as a plant flavonoid and strong antioxidant on testis histological changes and Spermatogenesis indexes in adult mice following treatment with Dexamethasone. Methods: 24 adu...
[ 13 ] - The Protective Effect of Quercetin on Sperm Parameters and Serum Biochemical Factors in Adult Mice Treated with Dexamethasone
Background and Objectives: Dexamethasone is a synthetic glucocorticoid, which causes oxidative stress in the testicular tissue. This study aimed to investigate the protective effect of quercetin as a powerful antioxidant on sperm parameters and serum biochemical factors in mature adult mice following the treatment with dexamethasone. Methods: In this experimental study, 24 mature adult male ...
[ 14 ] - PROTECTIVE EFFECT OF PENTOXIFYLLINE ON LIVER INJURY INDUCED BY DEXAMETHASONE IN MICE
Background & Aims: Dexamethasone (Dex) is one of the most commonly used synthetic glucocorticoidbut its excessive intake can cause severe changes in liver function. The purpose of the study was to investigate the effect of pentoxifylline (PTX) on Dex-induced hepatic injury in mice. Materials & Methods: 24 adult male NMRI mice (36±2gr) were divided randomly into 4 groups (n=6): control, dexamet...
[ 15 ] - Protective Effect of Pentoxifylline on Sperm and Biochemical Parameters against Dexamethasone-Induced Toxicity in Mice
Background and purpose: Nowadays, the side effects of chemical drugs such as dexamethasone, as a steroidal anti-inflammatory factor, is considered on reducing male reproductive potential. The aim of this study was to evaluate the effect of pentoxifylline on sperm parameters and biochemical factors in mice treated with dexamethasone. Materials and methods: In this study, 24 adult male NMRI mice...
[ 16 ] - N-Acetylcysteine Compared to Metformin, Improves The Expression Profile of Growth Differentiation Factor-9 and Receptor Tyrosine Kinase c-Kit in The Oocytes of Patients with Polycystic Ovarian Syndrome
Objective Paracrine disruption of growth factors in women with polycystic ovarian syndrome results in production of low quality oocyte, especially following ovulation induction. The aim of this study was to investigate the effects of metformin (MET), N-acetylcysteine (NAC) and their combination on the hormonal levels and expression profile of GDF-9, BMP-15 and c-Kit, as hallmarks of oocyte qual...
[ 17 ] - An analysis of rhetorical beauties in the interpretation of verses on embryology
The Holy Quran in various verses has explained stages of human development in embryonic period. The Quran describes these stages to prove the possibility of human resurrection after death. The present study seeks to substantiate this point that these verses, which contain scientific hints and wonders, have also rhetorical and phonetic beauty. The literary and scientific interpretation of the ve...
[ 18 ] - The Effects of Quercetin on the Tissue Quality and Function of Mouse Au-totransplanted Ovary
Background and Objectives: Ischemia-Reperfusion injury, followed by the production of oxygen free radi-cals and oxidative stress are the main limitations of ovarian tissue transplantation. We aimed to investi-gate the effects of quercetin as an antioxidant on the quality of autotransplanted mouse ovaries. Methods: In total, 36 female NMRI mice were divided into 3 groups of control, autografted,...
[ 19 ] - The effects of Vitamin C on quality of semen, testicular tissue, and level of apoptosis in mice exposed to sodium arsenite
Background: Arsenic as a heavy metal exerts malformation and changes in the reproductive system of men via induction of oxidative stress. We sought to investigate the impact of Vitamin C (Vit C), as a potent antioxidant, on sperm quality and testicular tissue in mice that received sodium arsenite. Methods and materials: NMRI mice were classified into four groups: control, sodium arsenite (7 mg...
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