Ali Shayanfar
Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
[ 1 ] - Effect of Pioglitazone on Plasma Levels of Phenytoin in Rats
Introduction: Interaction between drugs represents a major clinical concern for health care professionals and their patients. Patients affected by both type 2 diabetes and epilepsy may be prescribed pioglitazone and an anti-epileptic drug such as phenytoin concurrently. The aim of this study was to consider the interaction of pioglitazone with phenytoin in an experimental model. According to t...
[ 2 ] - Predicting Protein Binding of Drugs Using Abraham Parameters: Effect of Ionization
Background and purpose: Protein binding (PB) is an important pharmacokinetic parameter in drug discovery and development. In past years Abraham parameters were used to predict some physicochemical and pharmacokinetic properties of drugs. But in these cases, the ionization of drugs in blood pH (7.4) was ignored. Recently, Abraham parameters of chemical compounds in ionized form are proposed. Als...
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