gholamali naderi
Associate Professor - Department of Biochemistry, School of Medicine, Shahed University, Tehran, Iran
[ 1 ] - A study on inhibitory effect of ethanolic extract of the Pistacia lentiscus on acetylcholinesterase activity
Background and Objective: Changes of the enzyme acetylcholinesterase are involved in pathogenesis of different nervous disorders including Alzheimer’s disease. This research work was conducted to evaluate the inhibitory effect of Pistacia lentiscus ethanolic extract on acetylcholinesterase activity. Materials and Methods: Activity of the enzyme acetylcholinesterase (AChE) was measured by Ellman...
[ 2 ] - مقایسۀ اثرات مهارکنندگی دو داروی فیزوستیگمین و پروکائین بر روی فعالیت آنزیم استیل کولین استراز
Background and Objective: The acetylcholinesterase (AChE) is an enzyme that takes responsibility for substrate hydrolysis of acetylcholine, and it is seen structurally, as monomer, dimer and tetramer units. The objective of this study was to examine and compare the inhibitory effect of the two drugs, physostigmine and p hydrochloride in vitro. Materials and Methods: In this study, the in...
[ 3 ] - بررسی اثر مهارکنندگی عصاره اتانولی گیاه سعد کوفی (Cyperusrotandus) بر روی آنزیم استیل کولین استراز
مقدمه: زوال عقل (Dementia) کاهش پیشرونده در تواناییهای درکی و شناختی است، که ممکن است به علت بیماری یا صدمه به مغز ایجاد شود. دمانس انواع مختلفی دارد که شایعترین آن بیماری آلزایمر است. استیل کولین (acetylcholine) یکی از واسطه های شیمیایی مغز است که در ثبت، نگهداری و یادآوری اطلاعات در مغز نقش کلیدی دارد. سلول های عصبی ترشح کننده ی این ماده در زمره ی نخستین سلول هایی هستند که از تغییرات آسیب...
[ 4 ] - The effect of Foeniculum vulgare (Fennel) hydroalcoholic extract on serum lipid profiles and liver enzymes in male rats fed a high cholesterol regimen
Background and Objective: F. vulgare is used in traditional medicine for a wide range of ailments and has hepatoprotective, hypolipidemic and cardiovascular activities. This study was done to evaluate the effect of F. vulgare hydroalcoholic extract on serum lipid profiles and liver enzymes in adult Wistar rats. Materials and Methods: In this experimental study, 28 male rats (190-220 g) were div...
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