Jamshid Narenjkar
Department of Pharmacology, School of Medicine, Shahed University of Medical sciences, Tehran, Iran
[ 1 ] - Ameliorative activity of co-administration of ketamine and ECT on depression like behaviors in depressed rats
Background and Objective: Electroconvulsive therapy (ECT) is the end choice treatment for patients with major depressive disorder (MDD). Regarding researches that show NMDA receptor inactivation could yield the same results as anti-depressant drugs, however, the present study examined co-administration of ECT and ketamine (as NMDA antagonist) on depressed rat behaviors. Materials and Methods...
[ 2 ] - The Effect of Withania somnifera Alcoholic Extract on Learning and Memory Disturbance in a Model of Temporal Lobe Epilepsy in the Rat
Background and Objective: Temporal lobe epilepsy (TLE) usually leads to memory deficit. In this study, we tried to assess the effect of Withania somnifera extract on the impaired learning and memory in the intrahippocampal kainate model of TLE in the rat. Materials & Methods: Male rats (n=32) were divided into sham, extract+sham, kainite, and kainite+extract. For induction of epilepsy, unilate...
[ 3 ] - The effect of saffranal on intracerebroventricular strepto-zotocin-induced cognitive deficits in rat
Background and Objective: Intracerebroventricular (ICV) injection of streptozotocin (STZ) causes cognitive impairment in rats. The beneficial effect of saffron main component, safranal was investigated on ICV STZ-induced learning, memory, and cognitive impairment in male rats. Materials and Methods: For this purpose, rats were injected with ICV STZ bilaterally, on days 1 and 3 (3 mg/kg). The ST...
[ 4 ] - ارزیابی یادگیری و حافظه موش صحرایی صرعیشده توسط تزریق داخلهیپوکمپی اسید کاینیک پس از دریافت بربرین
Background and Objective: Epilepsy is the second most common disease of the central nervous system. Since memory disturbance is rather commin in epileptic patients, 20, the goal of this study was to assess the effect of berberine on memory deficit in epileptic rats. Materials and Methods: In this study, 32 male rats weighing 190-240 g were divided into 4 groups: sham, sham receiving berberi...
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