V. K. Dumka
Department of Pharmacology and Toxicology, College of Veterinary Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004, India
[ 1 ] - Pharmacokinetics, dosage regimen and in vitro plasma protein binding of intramuscular levofloxacin in buffalo calves
The pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. Peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above MIC90 in plasma was detected up to 12 h of administration. The bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1....
[ 2 ] - Kinetic disposition, urinary excretion and dosage regimen of subcutaneously administered levofloxacin in cross bred calves
The present study was conducted on five healthy male cross bred calves to study the kinetic dispositionand urinary excretion of levofloxacin following its single subcutaneous administration at the dose of4 mg.kg-1. The concentration of levofloxacin in plasma and urine samples was estimated by microbiologicalassay. Peak plasma level of levofloxacin (2.8 ± 0.3 μg.ml-1) was observed at 45 min and ...
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