Mohammad Kazem Koohi
Toxicology division, Basic science department, Faculty of veterinary medicine, University of Tehran, Tehran, Iran
[ 1 ] - Effect of sub acute exposure of nano Zinc particles on oxidative stress parameters in rats
BACKGROUND: Zinc (Zn) is one of the most important essential elements in the body of animals and plants. Zinc plays a significant role in the structure of more than 300 different proteins and in many life supporting biochemical and metabolic processes such as cellular respiration and protection against free radicals. Nanoparticles of zinc are the new form of Zinc used in cosmetic and personal c...
[ 2 ] - Transcriptional effects of metal ions on the bovine oxytocin and the thymidine kinase-ERE promoter through the estrogen receptor a in MDA-MB 231 breast cancer cell line
BACKGROUND: Some of metal ions as environmental pollutants show estrogenic activity. This xenostrogenic compounds can be caused carcinogenicity in organs. The mechanism of carcinogenicity of metal ions is not clarified. OBJECTIVES: In this study, we investigated the Transcriptional effects of variety of metal ions on the bovine oxytocin and the thymidine kinase-ERE promoter by estrogen receptor...
[ 3 ] - The pretreatment effects of pentoxifylline on aflatoxin B1-induced oxidative damage in perfused rat liver
This study was conducted to investigate the hepatoprotective and antioxidant effects of pentoxifylline (PTX) against aflatoxin B1 (AFB1) exposure in perfused rat livers by evaluating damage marker enzymes, antioxidant defense systems (glutathione, GSH) and lipid peroxidation (malondialdehyde, MDA). Sixteen rats were divided randomly into four experimental groups: control, PTX, AFB1 and AFB1 + P...
[ 4 ] - Toxicity of manufactured copper nanoparticles - A review
The health effects of nanoparticles (NPs) are raising considerable and growing concerns from the public and government around the world. Nano-metals are new forms of metal with special properties, but are characterized by having a particle size of less than 100 nm. Copper is an essential trace element and its deficiency leads to different diseases in humans. In gen...
[ 5 ] - Toxicopathological examinations after repeated intraperitoneal administration of silver nanoparticles in the Wistar rat model
Objective(s): Due to wide range of medical applications as bactericidal agents, nanosilver particles (NSPs) are manufactured worldwide in large quantities. However, potential toxicity impacts of NSPs in humans and animals still remain poorly understood. The objective of this study was to investigate clinical observations, mortality and pathological changes in rats follow...
[ 6 ] - Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitro
Objective(s): Evaluation of nanomaterials interaction with blood ingredients is a part of preclinical risk assessment of newly-synthesized materials, especially for nano-sized pharmaceuticals which are intravenously administrated. The red blood cells (RBCs) are susceptible to oxidative stress damage. This study was designed to evaluate induced oxidative hematotoxic effect of na...
[ 7 ] - ارزیابی اثرات اسید اولئیک در پیشگیری از لیپو توکسیسیتی ناشی از اسید پالمیتیک در سلول های قلبی کشت شده موش های صحرایی
مقدمه: یافته های متعدد حکایت از آن دارد که تاثیر اسیدهای چرب اشباع و غیر اشباع در بروز لیپو توکسیسیتی سلولی متفاوت از هم می باشند. برخی از اسید های چرب نظیر اسیداولئیک در جلوگیری از بروز لیپو توکسیسیتی در سلول های کبدی موش موثر بودند. هدف از این مطالعه، بررسی تاثیر اسید اولئیک بر شاخصه های لیپو توکسیسیتی در سلول های کشت شده عضله قلبی موش می باشد. مواد روش ها: سلول های بطنی قلب موش صحرایی در پ...
[ 8 ] - تاثیرات مواجهه مزمن استات سرب بر واکنش به تحریکات دردناک در موش سوری
Introduction: Influences of lead on functions of many organ systems are known, but less experimental studies has been done on influences over the behavior, including pain sensation. This study was carried out to reveal possible changes in the onset and intensity of reactions to painful stimuli in mice, after long-term exposure to lead acetate. Methods: In this experimental study, 24 adult ma...
[ 9 ] - Transcriptional effects of Organochlorine o,p′-DDT and its Metabolite p,p′-DDE in Transfected MDA-MB 231 and MCF-7 Breast Cancer Cell Lines
Background: The organochlorine DDT has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. In the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-DDT [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-DDE (2-2-bis(4/chlorophenyl)-1-1-di...
[ 10 ] - Estrogenic Activity of Some Phytoestrogens on Bovine Oxytocin and Thymidine Kinase-ERE Promoter through Estrogen Receptor-α in MDA-MB 231 Cells
Background: Phytoestrogens, a group of plant-derived polyphenolic compounds have recently come into considerable attention due to the increasing information on their potential adverse effects in human health. Some of phytoestrogens show estrogenic activity that may be carcinogenic for human. In the present study, we investigated the transcriptional effects of variety of phytoestrogens ...
[ 11 ] - خالص سازی توکسین اپسیلون از سویه واکسینال کلستریدیوم پرفرنژنس تیپ D با استفاده از کروماتوگرافی تبادل یون و ژل فیلتراسیون
باکتری کلستریدیوم پرفرنژنس تیپ D در بره‌ها، گوساله‌ها، کره اسب‌ها، بچه خوک‌ها و جوجه‌ها باعث ایجاد بیماری انتروتوکسمی یا pulpy kidney میشود. هم‌چنین در انسان، عامل بیماری enteritis necroticans می‌باشد. مهم‌ترین توکسین تیپ D توکسین اپسیلون است. این توکسین به عنوان مهم‌ترین فاکتور ویرولانس باکتری کلستریدیوم پر فرنژنس تیپ D در بیماری‌زایی به شمار می‌رود. در مطالعه‌ی حاضر، عملیات خالص‌سازی...
[ 12 ] - TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment
Background: The safety evaluations of sunscreens containing Titanium Dioxide-Nanoparticles (TiO2-NPs) were done by dermal exposure, acute dermal and eye irritation/corrosion, and skin sensitization according to the guideline for Organization for Economic Co-operation and Development (OECD). OBJECTIVES: The aim of our study was the evaluation of safety and toxicity of TiO2-NPs following acute su...
[ 13 ] - The Effect of Long-term Exposure to Aspartame on Histomorphometric and Histochemical Adrenal Gland in Adult NMRI Mice
Abstract Background & aim: Aspartame is an artificial sweetener that has been used extensively in over 200 million people in more than 90 countries in various food products and pharmaceuticals. There are many controversial reports about the toxicity of aspartame on various tissues of the body. Therefore, the aim of the present study was to determine the effect of long-term aspartame on histomor...
[ 14 ] - Cultural and social explanation of the water consumption in agriculture with emphasis on agricultural attitude measurement in Garmsar County
The statistical population of this study is all farmers in Garmsar County, which according to the statistics of the Agricultural Department, the number of them is 5675 people. Of these, 366 people were selected randomly according to the Cochran formula, and information were gathered through a researcher-made questionnaire. The research method is quantitative and we have tried to use the multiva...
[ 15 ] - مطالعه اثر پوشش کیتوزان حاوی اسانس کاکوتی کوهی بر برخی خصوصیات میکروبی و حسی فیله مرغ در دمای یخچالی
زمینۀ مطالعه: گوشت مرغ جزء غذاهای فسادپذیر تقسیمبندی میشود و یکی از نگرانیهای صنایع غذایی فساد میکروبی آن می‌باشد. هدف: هدف از این مطالعه ارزیابی اثر پوشش کیتوزان حاوی غلظت های مختلف اسانس کاکوتی کوهی در مقایسه با گروه شاهد بر برخی خصوصیات حسی و میکروبی فیله مرغ در طول 12 روز نگهداری در دمای یخچالی (۴ درجه سانتیگراد) بود. روش‌کار: در این مطالعه، اسانس گیاه کاکوتی کوهی به روش تقطیر با آب اس...
[ 16 ] - Effects of Chronic Contact with Low Levels of Lead Acetate on Learning in Active Mice Avoidance Conditional Approach
Introduction: Lead (Pb) is a major pollutant in the environment, which, upon long exposure, can impose a broad range of abnormalities in the structure and function of the brain, especially in the infant. Despite the efforts made in the behavioral effects of lead on the results, there are contradictions and conflicts. In this study, we assessed the effect of chronic exposure to low levels of lea...
[ 17 ] - Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats
Iron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. This study aimed to investigate the acute toxicity effects of IONPS in laboratory animals regarding p...
[ 18 ] - Investigation of Geological and Environmental Factors of Airborne Suspended Particles from Sand and Gravel Quarries in The West of Tehran, Iran
Introduction: Particulate matter (PM) is known as the most common cause of air pollution in the world. Activities of sand quarries are known as one of the emission sources in Tehran. This study aimed at investigating the geological and environmental factors of airborne particles in an active quarry in the west of Tehran. Material and Methods: Three methods of dust sampling were used. totally, ...
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