Rezvan Zabihollahi
1- Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran. 2- Medical school, Isfahan Medical Sciences University, Isfahan, Iran.
[ 1 ] - Inhibitory Activity of Avicennia marina, a Medicinal Plant in Persian Folk Medicine, against HIV and HSV
Avicennia marina (Avicenniaceae) is a species of mangrove tree used for treatment of small pox lesions in Persian folk medicine. The antiviral activity of methanol, ethanol, water, chloroform and n-hexane extracts was evaluated against HIV-1 and HSV. Methanol extract had the highest antiviral activity and the most polar fraction of this extract (fraction D) inhibited HSV with TI and SI values o...
[ 2 ] - Inhibitory Activity of Avicennia marina, a Medicinal Plant in Persian Folk Medicine, against HIV and HSV
Avicennia marina (Avicenniaceae) is a species of mangrove tree used for treatment of small pox lesions in Persian folk medicine. The antiviral activity of methanol, ethanol, water, chloroform and n-hexane extracts was evaluated against HIV-1 and HSV. Methanol extract had the highest antiviral activity and the most polar fraction of this extract (fraction D) inhibited HSV with TI and SI values o...
[ 3 ] - بهینه‌سازی بررسی میزان همانندسازی ویروس کمبود ایمنی انسانی تیپ یک با استفاده از ویریون‌های با قابلیت یک سیکل تکثیر
سابقه و هدف: ویریون مربوط به ویروس کمبود ایمنی انسانی (HIV) با قابلیت همانندسازی در پژوهش‌های مربوط به HIV مانند پژوهش‌هایی با هدف یافتن ترکیبات ضد ویروسHIV جدید مورد نیاز است. در این مطالعه، همانندسازی HIV-1 با استفاده از ویریون‌های با قابلیت یک سیکل تکثیر (SCR) انجام شد. روش بررسی: ویریون SCR به وسیله ترانسفکت کردن سلول‌های HEK293T با پلاسمیدهای pmzNL4-3 ، pSPAX2 و pMD2G تولید شد. سلول‌های ...
[ 4 ] - Design, Synthesis, Molecular Modeling, In Silico ADME Studies and Anti-HIV-1 Assay of New Diazocoumarin Derivatives
Some new diazo incorporated coumarin compounds were designed and synthesized to evaluate their anti-HIV activity. Overall, compounds were active against HIV at 100 μM. Additionally, no cytotoxic effect was observed at this concentration. The compound with 4-chlorobenzyl group indicated the best anti-HIV activity (52%). Docking studies using the later crystallographic data available for PFV inte...
[ 5 ] - Design, Synthesis, Molecular Modeling, In Silico ADME Studies and Anti-HIV-1 Assay of New Diazocoumarin Derivatives
Some new diazo incorporated coumarin compounds were designed and synthesized to evaluate their anti-HIV activity. Overall, compounds were active against HIV at 100 μM. Additionally, no cytotoxic effect was observed at this concentration. The compound with 4-chlorobenzyl group indicated the best anti-HIV activity (52%). Docking studies using the later crystallographic data available for PFV inte...