Ali Gudarzi
Department of medicinal chemistry, school of pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
[ 1 ] - Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfac...
[ 2 ] - Synthesis and Evaluation of New Fluorinated Anti-Tubercular Compounds
Treatment of tuberculosis (TB) and the discovery of effective new anti tubercular drugs is one of the most urgent priorities in health organizations all around the world. In the present study, fluorinated analogs of some of the most important anti-TB agents such as p-aminosalicylic acid (PAS), thiacetazone and pyrazinamide were synthesized and tested against TB. The fluorinated analog of thiace...
[ 3 ] - Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfac...
[ 4 ] - Synthesis and Evaluation of New Fluorinated Anti-Tubercular Compounds
Treatment of tuberculosis (TB) and the discovery of effective new anti tubercular drugs is one of the most urgent priorities in health organizations all around the world. In the present study, fluorinated analogs of some of the most important anti-TB agents such as p-aminosalicylic acid (PAS), thiacetazone and pyrazinamide were synthesized and tested against TB. The fluorinated analog of thiace...
[ 5 ] - Development and Validation of a GC/MS Method for Simultaneous Determination of 7 Monoterpens in Two Commercial Pharmaceutical Dosage Forms
Terpenes are active constituents of many pharmaceutical dosage forms with naturalproducts origin. One of the challenges in developing dosage forms with herbal originis their standardization as pharmaceutical products. GC-Mass is the most decisive andreliable technique to fulfill the requirements in this regard. In the present study, a reliable,rapid, and accurate method was developed for determ...
[ 6 ] - Development and Validation of a GC/MS Method for Simultaneous Determination of 7 Monoterpens in Two Commercial Pharmaceutical Dosage Forms
Terpenes are active constituents of many pharmaceutical dosage forms with naturalproducts origin. One of the challenges in developing dosage forms with herbal originis their standardization as pharmaceutical products. GC-Mass is the most decisive andreliable technique to fulfill the requirements in this regard. In the present study, a reliable,rapid, and accurate method was developed for determ...