Ghorbangol Ashabi
Department of Physiology, Faculty of Medicine-Physiology research center, Jundishapour Medical Sciences University, Ahwaz, Iran
[ 1 ] - Ameliorating of Memory Impairment and Apoptosis in Amyloid β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy
It has been proposed that appearance of amyloid beta (Aβ) in hippocampus is one of the characteristic features of Alzheimer’s disease (AD). The role of Nitric oxide (NO) in neurodegenerative disorders is controversy in different contexts. Here, we examined the effect of NO on spatial memory. For this purpose, we compared the effects of three different concentrations of L-NG-Nitroarginine Methyl...
[ 2 ] - Ameliorating of Memory Impairment and Apoptosis in Amyloid β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy
It has been proposed that appearance of amyloid beta (Aβ) in hippocampus is one of the characteristic features of Alzheimer’s disease (AD). The role of Nitric oxide (NO) in neurodegenerative disorders is controversy in different contexts. Here, we examined the effect of NO on spatial memory. For this purpose, we compared the effects of three different concentrations of L-NG-Nitroarginine Methyl...
[ 3 ] - Executive functions are related to serum testosterone and basal metabolism rate fluctuation but not lymphocyte dopamine receptor expression in the young healthy participants
Introduction: Herein, we evaluated linkages between EFs performances and dopamine receptor (DR) mRNA and testosterone level in the young Iranian male people. Methods: All 140 participants were normalized using depression, anxiety and stress scale questionnaire. Remained 108 volunteers were tested against drug abuse and then volunteers were distinguished by Wisconsin Card Sorting Test (WSC...
[ 4 ] - Gemfibrozil protect PC12 cells through modulation of Estradiol receptors against oxidative stress
Introduction: Neurodegenerative diseases are progressive disorders that could impair neuronal functions and structures. Oxidative stress and mitochondrial dysfunction are involved in the etiology of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and etc. Gemfibrozil is used as a therapeutic drug for hyperlipidemia. It has been shown that gemfibrozil is n...
[ 5 ] - A comprehensive approach to investigate the contradictory effects of metformin therapy in cerebral ischemic injury
Ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. Metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. Metformin can either protect or damage cells by activating AMP-activated protein kinase (AMPK) and its downstream factors so, it has a dual role in the cerebral ischemia context, bu...
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