Mahdi Mashhadi Akbar Boojar
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
[ 1 ] - New Aspects of Silibinin Stereoisomers and their 3-O-galloyl Derivatives on Cytotoxicity and Ceramide Metabolism in Hep G2 hepatocarcinoma Cell Line
Ceramide as a second messenger is a key regulator in apoptosis and cytotoxicity. Ceramide-metabolizing enzymes are ideal target in cancer chemo-preventive studies. Neutral sphingomyelinase (NSMase), acid ceramidase (ACDase) and glucosyl ceramide synthase (GCS) are the main enzymes in ceramide metabolism. Silymarin flavonolignans are potent apoptosis inducers and silibinin is the most active com...
[ 2 ] - New Aspects of Silibinin Stereoisomers and their 3-O-galloyl Derivatives on Cytotoxicity and Ceramide Metabolism in Hep G2 hepatocarcinoma Cell Line
Ceramide as a second messenger is a key regulator in apoptosis and cytotoxicity. Ceramide-metabolizing enzymes are ideal target in cancer chemo-preventive studies. Neutral sphingomyelinase (NSMase), acid ceramidase (ACDase) and glucosyl ceramide synthase (GCS) are the main enzymes in ceramide metabolism. Silymarin flavonolignans are potent apoptosis inducers and silibinin is the most active com...
[ 3 ] - مروری بر نقش اسفنگولیپیدها در پدیده آپوپتوز
سابقه و هدف: سرطان یکی از بزرگترین معضلات نظام سلامت در جهان و شیمی‌درمانی همچنان رایج‌ترین راهکار برای درمان آن است. بخش گسترده‌ای از مطالعات این حوزه به بررسی رخداد آپوپتوز به‌عنوان عامل کلیدی ممانعت‌کننده گریز سلولها از سازوکارهای تنظیم چرخه سلولی اختصاص یافته است. هدف از این پژوهش، جمع‌بندی مطالعات صورت گرفته بر متابولیسم، مسیرهای پیام‌رسان و عوامل دارویی مؤثر بر اسفنگولیپیدهای دخیل در پدی...
[ 4 ] - A Review of Pharmacotherapy for Coronavirus Disease 2019 (COVID-19)
The epidemic of COVID-19 and its associated acute respiratory syndrome has posed an unprecedented challenge in identifying effective drugs to prevent and treat it. Due to the high prevalence of this disease and the high number of people at risk, medical staff needs accurate evidence regarding effective drug treatments for this infection. There is currently no effective treatment for COVID-19. B...