Farshid Noorbakhsh
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences
[ 1 ] - Repeated Administration of Mercury Accelerates Progression of Multiple Sclerosis through Mitochondrial Dysfunction
Multiple Sclerosis (MS) is a neurodegenerative and autoimmune disease that it’s molecular etiology and factors involving in its progression remains unknown. In this study for evaluation effect of mercuric on progression of MS we investigated the additive effect of mercuric sulfide on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (EAE) model of MS in C57BL/6 mi...
[ 2 ] - Ameliorating of Memory Impairment and Apoptosis in Amyloid β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy
It has been proposed that appearance of amyloid beta (Aβ) in hippocampus is one of the characteristic features of Alzheimer’s disease (AD). The role of Nitric oxide (NO) in neurodegenerative disorders is controversy in different contexts. Here, we examined the effect of NO on spatial memory. For this purpose, we compared the effects of three different concentrations of L-NG-Nitroarginine Methyl...
[ 3 ] - Repeated Administration of Mercury Accelerates Progression of Multiple Sclerosis through Mitochondrial Dysfunction
Multiple Sclerosis (MS) is a neurodegenerative and autoimmune disease that it’s molecular etiology and factors involving in its progression remains unknown. In this study for evaluation effect of mercuric on progression of MS we investigated the additive effect of mercuric sulfide on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (EAE) model of MS in C57BL/6 mi...
[ 4 ] - Ameliorating of Memory Impairment and Apoptosis in Amyloid β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy
It has been proposed that appearance of amyloid beta (Aβ) in hippocampus is one of the characteristic features of Alzheimer’s disease (AD). The role of Nitric oxide (NO) in neurodegenerative disorders is controversy in different contexts. Here, we examined the effect of NO on spatial memory. For this purpose, we compared the effects of three different concentrations of L-NG-Nitroarginine Methyl...
[ 5 ] - گیرنده‌های فعال شونده با پروتئیناز در سیستم عصبی، جنبه‌های فیزیولوژی و پاتولوژی
مقدمه: گیرنده‌های فعال شونده با پروتئیناز، خانواده‌ای متشکل از 4 گیرنده متصل شونده به G پروتئین هستند که با مکانیسم فعالسازی خاص آن‌ها مشخص می‌شود و مستلزم آشکار شدن لیگاند فعال کننده پروتئولیتیک است. تا به امروز چهار گیرنده PAR در انسان و پستانداران کشف شده است. هر چهار عضو خانواده PAR در سیستم عصبی بیان شده‌اند، جایی که نشان داده شده است، بر ریخت‌شناسی، تکثیر و عملکرد سلول عصبی تأثیر دارند. ب...
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