Akram Ranjbar
) Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
[ 1 ] - The effect of green tea extract on oxidative stress and spatial learning in Streptozotocin-diabetic rats
Diabetes mellitus is associated with distribution of cognitive functioning. Hyperglycemia Diabetes mellitus is associated with distribution of cognitive functioning. Hyperglycemia induced oxidative stress has been proposed as a cause of memory complications of diabetes including cognitive impairment. The aim of this study was to examine total green tea extract (TGTE), a potent free radical scav...
[ 2 ] - Propofol Attenuates Toxic Oxidative Stress by CCl4 in Liver Mitochondria and Blood in Rat
Anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet CCl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). Group I (control), while Group II was given CCl4 (3 mL /Kg/day, IP). Animals of Groups III received only propofol (10 mg/Kg/day, IP). Group IV was given propofol+ CCl4. Group V was admin...
[ 3 ] - The effect of green tea extract on oxidative stress and spatial learning in Streptozotocin-diabetic rats
Diabetes mellitus is associated with distribution of cognitive functioning. Hyperglycemia Diabetes mellitus is associated with distribution of cognitive functioning. Hyperglycemia induced oxidative stress has been proposed as a cause of memory complications of diabetes including cognitive impairment. The aim of this study was to examine total green tea extract (TGTE), a potent free radical scav...
[ 4 ] - Propofol Attenuates Toxic Oxidative Stress by CCl4 in Liver Mitochondria and Blood in Rat
Anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet CCl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). Group I (control), while Group II was given CCl4 (3 mL /Kg/day, IP). Animals of Groups III received only propofol (10 mg/Kg/day, IP). Group IV was given propofol+ CCl4. Group V was admin...
[ 5 ] - Experimental Study of Cerium Oxide Nanoparticles (CeNP) Against Malathion Induced Lung Oxidative Toxic Stress in Rats
Regardless of toxicity of nanoparticles, cerium oxide nanoparticles (CeNPs) are emerging as a multi-functional agent for biomedical purposes. On the other hand, Organophosphorus pesticides, like malathion, are inevitably found in the environment. The common involving pathway CeNPs and malathion share is oxidative stress. Therefore, we conducted this study to find the possible neutralizing or sy...
[ 6 ] - Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver
Objective (s): Cerium oxide nanoparticles nanoceria (CeNPs) is a novel nanoparticle that has great potential for the treatment of various diseases. This study aimed to investigate the effects of CeNPs on oxidative stress biomarkers in the liver of male rats. Materials and Methods: Twenty-four male Wistar rats were equally distributed into 4 groups (n=6/each). The first group was controlled and ...
[ 7 ] - مقایسه اثر N-استیل سیستئین و ویتامین D بر سمیت اکسیدانی بافت کبد در مسمومیت تحت حاد با پاراکوات
سابقه و هدف: پاراکوات عمدتاً به عنوان علفکش به کار میرود و سمیت آن از طریق افزایش گونههای فعال اکسیژن میتواند مسبب بیماری کبدی حاد و مزمن شود، این مطالعه به منظور مقایسه اثر N-استیل سیتئین (NAC) و ویتامین D (Vit D) بر سمیت اکسیدانی بافت کبد در مسمومیت تحت حاد با پاراکوات انجام شد. مواد و روشها: در این مطالعه تجربی 36 موش صحرایی نر ویستار آلبینو 8 هفتهای به‌صورت تصادفی به 6 گروه تقسیم شدند:...
[ 8 ] - EEffects of nano-curcumin and curcumin on the oxidant and antioxidant system of the liver mitochondria in aluminum phosphide-induced experimental toxicity
Objective(s): Aluminum phosphide (AlP) is commonly used pesticide which could cause poisoning mainly through the induction of oxidative stress. The present study aimed to evaluate the effects of nano-curcumin and curcumin on the oxidant and antioxidant system in the liver mitochondria using AIP-induced toxicity model.Materials and Methods: In this study, 36 male albino Wistar rats were ra...
[ 9 ] - Evaluation of the Protective Effects of Hydroalcoholic Extract of Satureja avromanica Against Malathion-induced Oxidative Stress in the Liver: An Experimental Study
Background: Studies have shown that organophosphorus pesticides such as malathion induces oxidative stress injury and tissue damage. Objectives: This research aimed to determine the effects of the hydroalcoholic extracts of Satureja avromanica (SA) on the liver function of malathion-poisoned animals. Methods: Twenty-eight rats were divided into four groups of the control, SA (20 mg/kg), mala...
[ 10 ] - Antioxidative Effects of Nano-curcumin on Liver Mitochondria Function in Paraquat-induced Oxidative Stress
Background: Paraquat (PQ), as the most widely used herbicide in agriculture, induces poisoning in humans and animals mainly through oxidative stress. This study aimed to investigate the protective effects of nano-curcumin compared with curcumin against PQ-induced mitochondrial dysfunction. Materials and Methods: Thirty-six Wistar rats were used in this study. They were separated into 6 groups...
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