Effat Souri

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[ 1 ] - Validated Spectrophtometric Method for Simultaneous Determination of Bupernorphine and Naloxone in Pharmaceutical Dosage Forms

Buprenorphine is a partial mu agonist and kappa antagonist which is used for the treatment of pain and opioid addiction. A mixture of buprenorphine hydrochloride and naloxone hydrochloride has been approved for the treatment of opioid dependence.In this study a third order derivative spectrophotometric method based on zero-crossing technique has been used for the simultaneous determination of b...

[ 2 ] - A Stability Indicating HPLC Method for the Determination of Fluvoxamine in Pharmaceutical Dosage Forms

Fluvoxamine maleate is a selective serotonin reuptake inhibitor, which is used for the treatment of different types of depressive disorders. In the present study, a stability indicating HPLC method was developed and validated for the determination of fluvoxamine maleate. The chromatographic separation was carried out using a Nova-Pak CN column and a mixture of K2HPO4 50 mM (pH 7.0) and acetonit...

[ 3 ] - Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets

A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. Determination of these drugs was perf...

[ 4 ] - Validated Spectrophtometric Method for Determination of Tamsulosin in Bulk and Pharmaceutical Dosage Forms

In this study a sensitive, simple and accurate spectrophotometric method was suggested for determination of tamsulosin in bulk powder and pharmaceutical dosage form based on the formation of an ion-pair complex between the drug and bromocresol green in a buffer solution at pH 3.5. The formed yellow color complex was extracted with chloroform and measured at 415 nm. The optimum reaction conditio...

[ 5 ] - Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions

A stability indicating High-Performance Liquid Chromatography (HPLC) method wasvalidated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidativeconditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mMKH2PO4 and acetonitrile (60:40 v/v, pH = 3.5) was used as the mobile phase. The method waslinear over the range of 1-20 μg/mL of ce...

[ 6 ] - The Effect of Otostegia persica in Combination with Chloroquine on Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium berghei Using In-vivo Fixed Ratios Method

   Malaria is one of the worldwide parasitic diseases which threaten the life of hundreds of millions of people at the malarious areas each year. The emergence of chloroquine-resistant strains of Plasmodium falciparum in most of the malarious areas has encountered the relevant countries with some difficulties about treating the acute cases of the disease particulary if the monotherapy regimen h...

[ 7 ] - Validated Spectrophtometric Method for Simultaneous Determination of Bupernorphine and Naloxone in Pharmaceutical Dosage Forms

Buprenorphine is a partial mu agonist and kappa antagonist which is used for the treatment of pain and opioid addiction. A mixture of buprenorphine hydrochloride and naloxone hydrochloride has been approved for the treatment of opioid dependence.In this study a third order derivative spectrophotometric method based on zero-crossing technique has been used for the simultaneous determination of b...

[ 8 ] - A Stability Indicating HPLC Method for the Determination of Fluvoxamine in Pharmaceutical Dosage Forms

Fluvoxamine maleate is a selective serotonin reuptake inhibitor, which is used for the treatment of different types of depressive disorders. In the present study, a stability indicating HPLC method was developed and validated for the determination of fluvoxamine maleate. The chromatographic separation was carried out using a Nova-Pak CN column and a mixture of K2HPO4 50 mM (pH 7.0) and acetonit...

[ 9 ] - Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets

A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. Determination of these drugs was perf...

[ 10 ] - Validated Spectrophtometric Method for Determination of Tamsulosin in Bulk and Pharmaceutical Dosage Forms

In this study a sensitive, simple and accurate spectrophotometric method was suggested for determination of tamsulosin in bulk powder and pharmaceutical dosage form based on the formation of an ion-pair complex between the drug and bromocresol green in a buffer solution at pH 3.5. The formed yellow color complex was extracted with chloroform and measured at 415 nm. The optimum reaction conditio...

[ 11 ] - Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions

A stability indicating High-Performance Liquid Chromatography (HPLC) method wasvalidated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidativeconditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mMKH2PO4 and acetonitrile (60:40 v/v, pH = 3.5) was used as the mobile phase. The method waslinear over the range of 1-20 μg/mL of ce...

[ 12 ] - The Effect of Otostegia persica in Combination with Chloroquine on Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium berghei Using In-vivo Fixed Ratios Method

   Malaria is one of the worldwide parasitic diseases which threaten the life of hundreds of millions of people at the malarious areas each year. The emergence of chloroquine-resistant strains of Plasmodium falciparum in most of the malarious areas has encountered the relevant countries with some difficulties about treating the acute cases of the disease particulary if the monotherapy regimen h...

[ 13 ] - ارزیابی فعالیت آنتی‌اکسیدان 25 دانه گیاه مورد مصرف در طب سنتی ایران

آنتی‌اکسیدان‌ها ترکیباتی حیاتی هستند که دارای خاصیت محافظت بدن از صدمات ناشی از استرس‌های اکسیداتیو می‌باشند. انواع مختلفی از آنتی‌اکسیدان‌ها در بدن موجودات زنده وجود دارد که بسیاری ازآنها از منابع غذایی مانند میوه، سبزیجات و نوشیدنی‌ها تامین می‌شود. دراین مطالعه خاصیت آنتی‌اکسیدان تعداد 25 دانه گیاهی مورد مصرف در طب سنتی در مقابل پراکسیداسیون لینولئیک اسید با استفاده از معرف 1و3- دی اتی...

[ 14 ] - بررسی فعالیت آنتی‌اکسیدانی عصاره متانولی و فراکسیون‌های آن از گیاهSalvia verticillata L. با استفاده از سه روش متفاوت

مقدمه: آنتی‌اکسیدان‌ها ترکیبات مهمی هستند که محافظت بدن را در مقابل تخریب ناشی از استرس‌های اکسیداتیو در اثر رادیکال‌های آزاد بر عهده دارند. انواع متفاوتی از مهارکننده‌های رادیکالی در بدن موجود است که اغلب آنها از رژیم غذایی مانند میوه‌ها، سبزیجات و نوشیدنی‌ها تامین می‌شوند. هدف: در این بررسی فعالیت آنتی‌اکسیدانی گیاهSalvia verticillata با استفاده از سه روش مختلف بررسی شده است. روش بررسی: در...

[ 15 ] - Development and Validation of a Rapid Derivative Spectrophotometric Method for Determination of Tropicamide in Eye Drops

      Tropicamide is an antimuscarinic agent used as eye drops for refractive examinations. The aim of this study was to develop a simple and suitable analytical method for determination of tropicamide in eye drops in the presence of excipients. A zero-crossing third and fourth derivative spectrophotometric method was described for determination of tropicamide in eye drops. The measurements wer...

[ 16 ] - Spectrophotometric Determination of Tropicamide in Bulk and Pharmaceutical Formulations

     A simple and sensitive extractive spectrophotometric method is described for determination of tropicamide. The method is based on the reaction of tropicamide and bromocresol green. The ion-paired colored complex was extracted with chloroform at pH 3. The extracted complex showed maximum absorbance at 423 nm. The complex was stable up to 2 days and obeyed Beer's law over the concentration r...

[ 17 ] - Determination of Glycyrrhetic Acid in Rat Plasma by HPLC After Oral Administration of Licorice Aqueous Extract

     Licorice is obtained from Glycyrrhiza glabra (G. glabra) in Iran. Glycyrrhizin is the main constituent of G. glabra and has several pharmacological effects. It is hydrolyzed to glycyrrhetic acid (GA) in the intestine after oral administration. In this study, a novel HPLC method was used to determine the concentration of GA in rat plasma after oral administration ...

[ 18 ] - An Ex-Vivo Study on the Stereoselective Accumulation of Mefloquine Enantiomers in Human Blood Fractions

       Mefloquine (MFQ), as a racemic mixture is used for the prophylaxis and treatment of malaria. Stereoselective pharmacodynamic and pharmacokinetic differences have been observed for MFQ. In the present study, the human blood was spiked with racemic MFQ. The concentration of MFQ enantiomers in various blood fractions including packed erythrocyte layer, platelet rich plasma and platelet poor...

[ 19 ] - Synthesis of 6-(Phenanthrene-3-yl)-2,3-dihydro-1,2,4,-triazine-3-thione as a New Reagent for the Non-Extractive Spectrophotometric Determination of Cu(II)

A simple, sensitive, and non-extractive spectrophotometric method was developed for the determination of copper (II) using a newly synthesized chromogenic reagent, 6-(phenanthrene-3-yl)-1,2,4,-triazine-3-thione(PhDTT), in Tween 80 neutral surfactant. To synthesize the reagent (PhDDT), amyl nitrite was added to 3-acethylphenanthrene and refluxed for 26 hours to produce 2-oxo-2-(phenanthren-3...

[ 20 ] - Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation

Three rapid spectrophotometric methods were developed for the determination of sunitinib based on the formation of ion-pair complex in acidic medium with bromocresol purple, bromothymol blue, and bromophenol blue. The formed ion-pair complexes, extractable with chloroform, were measured at 422 nm for bromocresol purple, 425 nm for bromothymol blue and 427 nm for bromophenol blue. All these meth...

[ 21 ] - Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation

Three rapid spectrophotometric methods were developed for the determination of sunitinib based on the formation of ion-pair complex in acidic medium with bromocresol purple, bromothymol blue, and bromophenol blue. The formed ion-pair complexes, extractable with chloroform, were measured at 422 nm for bromocresol purple, 425 nm for bromothymol blue and 427 nm for bromophenol blue. All these meth...