Mahmoud Mosaddegh
Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical sciences, Tehran, Iran
[ 1 ] - Fabrication and physicochemical investigation of ancient Iranian and Pakistani treated silver particles and their comparison with silver nanoparticles
Iranian and Pakistani traditional physicians have derived the advantages of silver compounds by processing silver to a specific preparation called Kushta to treat skin cancers. This study investigated silver Kushtas in comparison with silver nanoparticles in the terms of morphology, silver content, and chemical composition. Materials and Methods: Iranian silver Kushta (IKAg) powder was produced...
[ 2 ] - Primula auriculata Extracts Exert Cytotoxic and Apoptotic Effects against HT-29 Human Colon Adenocarcinoma Cells
Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...
[ 3 ] - Antiplasmodial Activity and Cytotoxicity of Plants Used in Traditional Medicine of Iran for the Treatment of Fever
Malaria is the most serious parasitic disease and one of the oldest recorded diseases in the world. Because of the resistance of malaria parasites to current drugs, it is necessary to discover new antiplasmodial drugs. Traditional medicine is one of the important sources of new antiplasmodial drugs.In this study, twenty methanolic extracts from different parts of sixteen medicinal plants used i...
[ 4 ] - Chronic Cold-Water-Induced Hypothermia Impairs Memory Retrieval and Nepeta menthoides as a Traditional “Hot” Herb Reverses the Impairment
Iranian Traditional Medicine (ITM) describes a kind of dementia with similar signs and symptoms of Alzheimer’s disease (AD). It explains the pathology of dementia with cold intemperament of the brain, which means that the brain is colder than its healthy form. ITM strategy for treatment of dementia is to heat the brain up by medical “hot” herbs. Nepeta menthoides (NM) is one of these “hot” herb...
[ 5 ] - Cytotoxic Activity of Some Medicinal Plants from Hamedan District of Iran
Medicinal plants have been investigated for possible anti-cancer effects. The aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of Hamedan district of Iran. The methanolic extracts of the plants were prepared and th...
[ 6 ] - Fabrication and physicochemical investigation of ancient Iranian and Pakistani treated silver particles and their comparison with silver nanoparticles
Iranian and Pakistani traditional physicians have derived the advantages of silver compounds by processing silver to a specific preparation called Kushta to treat skin cancers. This study investigated silver Kushtas in comparison with silver nanoparticles in the terms of morphology, silver content, and chemical composition. Materials and Methods: Iranian silver Kushta (IKAg) powder was produced...
[ 7 ] - Primula auriculata Extracts Exert Cytotoxic and Apoptotic Effects against HT-29 Human Colon Adenocarcinoma Cells
Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...
[ 8 ] - Antiplasmodial Activity and Cytotoxicity of Plants Used in Traditional Medicine of Iran for the Treatment of Fever
Malaria is the most serious parasitic disease and one of the oldest recorded diseases in the world. Because of the resistance of malaria parasites to current drugs, it is necessary to discover new antiplasmodial drugs. Traditional medicine is one of the important sources of new antiplasmodial drugs.In this study, twenty methanolic extracts from different parts of sixteen medicinal plants used i...
[ 9 ] - Chronic Cold-Water-Induced Hypothermia Impairs Memory Retrieval and Nepeta menthoides as a Traditional “Hot” Herb Reverses the Impairment
Iranian Traditional Medicine (ITM) describes a kind of dementia with similar signs and symptoms of Alzheimer’s disease (AD). It explains the pathology of dementia with cold intemperament of the brain, which means that the brain is colder than its healthy form. ITM strategy for treatment of dementia is to heat the brain up by medical “hot” herbs. Nepeta menthoides (NM) is one of these “hot” herb...
[ 10 ] - Cytotoxic Activity of Some Medicinal Plants from Hamedan District of Iran
Medicinal plants have been investigated for possible anti-cancer effects. The aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of Hamedan district of Iran. The methanolic extracts of the plants were prepared and th...
[ 11 ] - Inhibition of Heme Polymerization, the Mechanism of Antimalarial Activity in Phlomis caucasica Rech.f. (Lamiaceae)
Background: Malaria is one of the most important parasitic diseases in the world caused by Plasmodium species. The malaria parasite digests hemoglobin in vacuole to amino acids and heme. Plasmodium has got several detoxification mechanisms to protect itself from toxic heme. The most important mechanism is heme polymerization. Identifying compounds that inhibit heme polymerization is an approach...